Webinar: Flow Chemistry as a Powerful Tool to Enable the Scale-up of APIs
Using Flow Chemistry to Mitigate Hazards Associated with Materials Used in Commercial Manufacturing and Piloting of Challenging Processes in Batch Mode
プログラム概要
- How a flow process was developed as a safe, cost-effective, and scalable cyanation process for the commercial manufacturing of an intermediate for Remdesivir.
- Designing a flow reactor with optimized mixing and temperature controls to enable a chemo- and regioselective DIBAL-H reduction of a diester.
- Demonstrate advantages of flow chemistry in place of batch chemical processes that have limitations in safety, heat transfer, and selectivity.
Flow chemistry has emerged as a powerful tool in the pharmaceutical industry, enabling the scale-up of active pharmaceutical ingredients (APIs) and mitigating the hazards associated with materials used in commercial manufacturing. In this presentation, Tim Gao of Gilead Sciences discusses the potential of using flow chemistry to facilitate the commercialization of challenging processes.
The webinar provides insights into the latest advancements in flow chemistry, highlighting the benefits of process intensification, rapid optimization, and improved safety. With the pharmaceutical industry facing increasing pressure to deliver high-quality products while reducing costs and environmental impact, the use of flow chemistry in API production represents a promising solution that can help meet these challenges.
Target Audience
Chemical Engineers or Scientists in Process R&D and Manufacturing
Presenter
Tim Gao
Sr. Research Scientist II, Gilead Sciences
Tim is a seasoned API and DP process development professional with 17 years of experience. He is specialized in mixing, unit operation scale-up and scale-down, and troubleshooting process issues that involve chemistry and engineering.
