反应动力学和机理研究
百时美施贵宝公司、斯克利普斯研究院和威斯康星大学研究人员介绍了两个较近发布的化学反应动力学研究示例。 这些示例强调如何将原位 FTIR 光谱与传统离线分析方法配合使用，以获得宝贵的洞察力、机理理解以及对所研究化学反应的模型验证。
Scientists must work with speed and accuracy to create commercially viable processes at multiple scales. Deliveries are made under stringent regulatory conditions. This is done with limited time and material available for detailed scientific investigations. This complex set of demands means scientists must find innovative methods to ask and answer the big questions. The references and resources below describe how scientists are approaching the this demanding challenge.
ReactIR™ Spectroscopy in Peer-Reviewed Publications
This free Citation List presents an extensive list of peer-reviewed publications related to the use of in-situ ReactIR spectroscopy for the advancement of chemical development, providing a valuable resource for researchers, students, and anyone interested in this fascinating field of study.
化学反应的原位监测
使用光谱学进行原位反应监测使科学家能够看到他们的化学反应在反应时发生了什么，并允许立即改变化学条件以加快工艺开发。
避免加氢反应副产物
本白皮书讨论了加氢反应中副产物生成的根本原因，以及如何在加氢反应期间避免副产物生成。
实时 反应监控白皮书：串联氢甲酰化/氢化
实时的原位中红外光谱反应监测有助于更好地了解催化剂的活性和稳定性。 东京大学的研究人员将此专业知识用于新的串联氢甲酰化/氢化过程。
ReactIR
通过原位FTIR光谱仪，科学家可以深入了解其在各种应用中的反应和过程。使用在线FTIR仪器优化反应变量。
Reaction Insight Challenges
- Reaction mechanism viability, conversion, and selectivity often remain unknown until late in the development cycle
- Scientists are unable to sample with the frequency needed to understand reaction kinetics
- Scientists rely on information obtained through visual observations which are sporadic, subjective, and rarely recorded
- Expensive and over-burdened analytical resources that should focus on quality control are often deployed to troubleshoot or optimize challenging reactions
- Many reaction steps require significant overhead to characterize (e.g. air sensitive, low temperature, and high pressure), meaning they are often not characterized at all
- The critical process parameters that influence the performance of a reaction are often not recorded