Sodium Borohydride Reduction: A Sustainable PAT System for Safe Operation

Roche's Innovative Approach to PAT Integration
This application note discusses a sustainable Process Analytical Technology (PAT) system using Process FTIR for the safe operation of a sodium borohydride reduction.  Roche Ireland uses an innovative approach to PAT integration that bridges the gap between PAT and Quality Control, while further integrating PAT as a routine manufacturing system.

In-process Mid-IR was key in providing a solution to Roche's process problems.  The goals for throughput, plant usage and manpower were achieved within a few weeks resulting in:

• Yield Improvement
• Zero Batch Failures
• Decrease From 8 Person Operation to 6 Person Operation
• Reduction in Manual Handling (Safety)
• Increase in Annual Profit