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In the pharmaceutical industry, there is significant pressure to improve bioprocessing measurements of parameters such as pH, DO and CO2. Meeting quality objectives while enhancing bioprocessing is a challenge many companies face.
Intelligent Sensor Management (ISM®) is a digital technology for in-line process analytics that incorporates intelligent algorithms into sensors and improves bioprocessing measurements. ISM provides real-time sensor diagnostics information, improves pharmaceutical measurements and process control, and maximizes process equipment availability. With ISM, sensor handling and maintenance management become simpler and more efficient.
The guide, "5 Ways to Improve Bioprocessing with Digital Sensors" contains the following five case studies:
Enhance Bioreactor Performance Integrating Digital pH & DO Sensors:
Tissue engineering demands the utmost accuracy and repeatability from sensor measurements. A manufacturer of cutting-edge bioreactors for tissue applications has selected METTLER TOLEDO ISM probes for their high reputation and problem-free integration.
Speed-up Process Development from Benchtop to Production:
The InPro® 5000i sensor from METTLER TOLEDO enables precise and reliable in-line measurement of dissolved CO2 throughout an entire cultivation period at variable gas transfer from liquid to gas phase.
Evaluate Respiratory Efficiency with Continuous CO2 Monitoring
In situ measurement of dissolved CO2 is a critical parameter in evaluating the respiratory efficiency of microorganisms in cell culture. Virginia Bioinformatics Institute used the METTLER TOLEDO in situ CO2 measurement system to study Saccharomyces cerevisiae cells (yeast) in batch culture in order to accurately and reproducibly determine the growth phase of the culture as a function of CO2.
Eliminate Electromagnetic Interference by Shifting from Analog Sensors:
Digital sensor technology does not suffer from sensor measurement and calibration issues caused by insufficient electrical isolation on analog equipment. METTLER TOLEDO digital pH and DO solutions have restored measurement confidence for one of Big Pharma‘s companies.
Reduce Maintenance Efforts Using Optical DO Measurement:
Amperometric dissolved oxygen (DO) sensors are abundant in pharmaceutical processes, but their requirement for regular maintenance results in high running costs. Optical DO sensor are an advanced, low maintenance alternative.
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