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On-line microbial monitoring provides real-time results of pharmaceutical companies' water quality, enabling better process control. A leading biotechnology company integrated the METTLER TOLEDO 7000RMS microbial detection analyzer for continuous bioburden measurement in order to enhance their water process control capabilities.
Conductivity and total organic carbon measurements have become standard process monitoring tools in the production of pharmaceutical waters. The biotechnology company wanted the same benefits of continuous, on-line measurement that they get from these traditional systems, and to apply the same concept to microbial contamination monitoring in their water system.
In addition to making their processes more efficient, the trending data provided by the 7000RMS has allowed the company to better understand their water system’s dynamics.
This biotechnology company identified several benefits of implementing the 7000RMS in their water system. In addition to a fast response to problems, they were also able to better manage their sanitization cycles and optimize rinse times. Labor costs have also been reduced as a result of less sampling and laboratory-based testing.
The METTLER TOLEDO 7000RMS analyzer detects microbial presence within seconds of a sample entering the analyzer. Measurements are continuously updated, providing a real-time profile of PW or WFI systems. This information enables you to quickly divert contaminated water before it impacts other locations within the water system.
The 7000RMS uses two well-established optical measurement techniques in combination to provide real-time data and process transparency into a pharmaceutical facility's water system. Using the 7000RMS at points-of-use, sub loops, or distribution loops will help you make informed decisions to ensure the required quality of water is released to production.
Continuous monitoring with the 7000RMS enables a more accurate and constant surveillance of a system’s water quality. On-line monitoring enables early indication of microbial excursions so that process and quality groups can ensure water used for manufacturing is always in compliance and always in control.
