Using AntiSolvent For Crystallization

How Solvent Addition Can Control Crystal Size and Count

Ring för offert
Guide to Crystallization Development
Supersaturation Profiling
Control Supersaturation and Size
Challenges with Supersaturation, Purity and Scale-up
Crystallization With Supersaturation Control

Applikationer

Applications For Antisolvent Addition on Supersaturation

Recrystallization
Optimization of Crystal Properties and Process Performance

Recrystallization is a technique used to purify solid compounds by dissolving them in a hot solvent and allowing the solution to cool. During this process, the compound forms pure crystals as the solvent cools, while impurities are excluded. The crystals are then collected, washed, and dried, resulting in a purified solid product. Recrystallization is an essential method for achieving high levels of purity in solid compounds.

Solubility and Metastable Zone Width (mzw) Determination
Byggnadsstenarna för kristallisation

Det är vanligt att använda löslighetskurvor för att illustrera relationen mellan löslighet, temperatur och typ av lösningsmedel. Genom att kartlägga temperatur kontra löslighet, kan vetenskapsmän skapa det ramverk som krävs för att utveckla önskad kristallisationsprocess. Så snart som ett lämpligt lösningsmedel har valts, blir löslighetskurvan ett viktigt verktyg för utvecklingen av en effektiv kristallisationsprocess.

övermättad kristallisation
Drivkraften för kristallkärnbildning och tillväxt

Forskare och tekniker får kontroll över kristallisationsprocesserna genom att omsorgsfullt justera övermättnadsnivån under processen. Övermättnad är drivkraften för kärnbildning och tillväxt under kristallisationen och styr den slutgiltiga kristallstorleksfördelningen.

Measure Crystal Size Distribution
Förbättra kristallisationen med inlinemätning av partikelstorlek, form och antal

Sondbaserade teknologier som används medan processen pågår tillämpas för att spåra storleks- och formförändringar för partiklar vid full koncentration utan behov av utspädning eller extraktion. Genom att spåra hastighet och förändringsgrad för partiklar och kristaller i realtid, kan de korrekta processparametrarna för kristallationsprestandan optimeras.

Crystallization Seeding Protocol
Design and Optimize Seeding Protocol for Improved Batch Consistency

Seeding is one of the most critical steps in optimizing crystallization behavior. When designing a seeding strategy, parameters such as seed size, seed loading (mass), and seed addition temperature must be considered. These parameters are generally optimized based on process kinetics and the desired final particle properties, and must remain consistent during scale-up and technology transfer.

Oiling Out in Crystallization
Detect and Prevent Oiling Out (Liquid-Liquid Phase Separation)

Liquid-Liquid phase separation, or oiling out, is an often difficult to detect particle mechanism that can occur during crystallization processes.

Anti-Solvent Addition on Supersaturation
How Solvent Addition Can Control Crystal Size and Count

In an antisolvent crystallization, the solvent addition rate, addition location and mixing impact local supersaturation in a vessel or pipeline. Scientists and engineers modify crystal size and count by adjusting antisolvent addition protocol and the level of supersaturation.

Temperature Effects Crystallization Size and Shape
Supersaturation Control Optimizes Crystal Size and Shape

Crystallization kinetics are characterized in terms of two dominant processes, nucleation kinetics and growth kinetics, occurring during crystallization from solution. Nucleation kinetics describe the rate of formation of a stable nuclei. Growth kinetics define the rate at which a stable nuclei grows to a macroscopic crystal. Advanced techniques offer temperature control to modify supersaturation and crystal size and shape.

Temperature Effects Crystallization Size and Shape
Scaling-Up Agitation, Dosing, and Crystallization

Changing the scale or mixing conditions in a crystallizer can directly impact the kinetics of the crystallization process and the final crystal size. Heat and mass transfer effects are important to consider for cooling and antisolvent systems respectively, where temperature or concentration gradients can produce inhomogeneity in the prevailing level of supersaturation.

Crystal Polymorphism
Understand Polymorphism and the Impact of Process Parameters

Crystal polymorphism describes the ability of one chemical compound to crystallize in multiple unit cell configurations, which often show different physical properties.

protein crystallization
Create Structured, Ordered Lattices for Complex Macromolecules

Protein crystallization is the act and method of creating structured, ordered lattices for often-complex macromolecules.

Lactose Crystallization
Recover Lactose with High Yield and Scalable Process

Lactose crystallization is an industrial practice to separate lactose from whey solutions via controlled crystallization.

Batch Crystallization Optimization and Process Design
Generate Supersaturation and Determine Final Crystal Product

A well-designed batch crystallization process is one that can be scaled successfully to production scale - giving the desired crystal size distribution, yield, form and purity. Batch crystallization optimization requires maintaining adequate control of the crystallizer temperature (or solvent composition).

Continuous Crystallization Processes
Real-Time Monitoring for Modeling and Control

Continuous crystallization is made possible by advances in process modeling and crystallizer design, which leverage the ability to control crystal size distribution in real time by directly monitoring the crystal population.

MSMPR crystallizer workstation
Improve Crystallization Experiments with Precise Control

The MSMPR (Mixed Suspension Mixed Product Removal) crystallizer is a type of crystallizer used in industrial processes to produce high-purity crystals.

Recrystallization

Recrystallization is a technique used to purify solid compounds by dissolving them in a hot solvent and allowing the solution to cool. During this process, the compound forms pure crystals as the solvent cools, while impurities are excluded. The crystals are then collected, washed, and dried, resulting in a purified solid product. Recrystallization is an essential method for achieving high levels of purity in solid compounds.

Solubility and Metastable Zone Width (mzw) Determination

Det är vanligt att använda löslighetskurvor för att illustrera relationen mellan löslighet, temperatur och typ av lösningsmedel. Genom att kartlägga temperatur kontra löslighet, kan vetenskapsmän skapa det ramverk som krävs för att utveckla önskad kristallisationsprocess. Så snart som ett lämpligt lösningsmedel har valts, blir löslighetskurvan ett viktigt verktyg för utvecklingen av en effektiv kristallisationsprocess.

övermättad kristallisation

Forskare och tekniker får kontroll över kristallisationsprocesserna genom att omsorgsfullt justera övermättnadsnivån under processen. Övermättnad är drivkraften för kärnbildning och tillväxt under kristallisationen och styr den slutgiltiga kristallstorleksfördelningen.

Measure Crystal Size Distribution

Sondbaserade teknologier som används medan processen pågår tillämpas för att spåra storleks- och formförändringar för partiklar vid full koncentration utan behov av utspädning eller extraktion. Genom att spåra hastighet och förändringsgrad för partiklar och kristaller i realtid, kan de korrekta processparametrarna för kristallationsprestandan optimeras.

Crystallization Seeding Protocol

Seeding is one of the most critical steps in optimizing crystallization behavior. When designing a seeding strategy, parameters such as seed size, seed loading (mass), and seed addition temperature must be considered. These parameters are generally optimized based on process kinetics and the desired final particle properties, and must remain consistent during scale-up and technology transfer.

Oiling Out in Crystallization

Liquid-Liquid phase separation, or oiling out, is an often difficult to detect particle mechanism that can occur during crystallization processes.

Anti-Solvent Addition on Supersaturation

In an antisolvent crystallization, the solvent addition rate, addition location and mixing impact local supersaturation in a vessel or pipeline. Scientists and engineers modify crystal size and count by adjusting antisolvent addition protocol and the level of supersaturation.

Temperature Effects Crystallization Size and Shape

Crystallization kinetics are characterized in terms of two dominant processes, nucleation kinetics and growth kinetics, occurring during crystallization from solution. Nucleation kinetics describe the rate of formation of a stable nuclei. Growth kinetics define the rate at which a stable nuclei grows to a macroscopic crystal. Advanced techniques offer temperature control to modify supersaturation and crystal size and shape.

Temperature Effects Crystallization Size and Shape

Changing the scale or mixing conditions in a crystallizer can directly impact the kinetics of the crystallization process and the final crystal size. Heat and mass transfer effects are important to consider for cooling and antisolvent systems respectively, where temperature or concentration gradients can produce inhomogeneity in the prevailing level of supersaturation.

Crystal Polymorphism

Crystal polymorphism describes the ability of one chemical compound to crystallize in multiple unit cell configurations, which often show different physical properties.

protein crystallization

Protein crystallization is the act and method of creating structured, ordered lattices for often-complex macromolecules.

Lactose Crystallization

Lactose crystallization is an industrial practice to separate lactose from whey solutions via controlled crystallization.

Batch Crystallization Optimization and Process Design

A well-designed batch crystallization process is one that can be scaled successfully to production scale - giving the desired crystal size distribution, yield, form and purity. Batch crystallization optimization requires maintaining adequate control of the crystallizer temperature (or solvent composition).

Continuous Crystallization Processes

Continuous crystallization is made possible by advances in process modeling and crystallizer design, which leverage the ability to control crystal size distribution in real time by directly monitoring the crystal population.

MSMPR crystallizer workstation

The MSMPR (Mixed Suspension Mixed Product Removal) crystallizer is a type of crystallizer used in industrial processes to produce high-purity crystals.

Trycksaker

Publications For The Antisolvent Addition on Supersaturation

White Papers

Kristallisering
Dynamiska mekanismer som är viktiga för att förstå kristalliseringsprocesser kan nu observeras med mikroskopi in situ. Ett White Paper förklarar hur l...
Crystallization Process pdf
This white paper introduces you to the fundamentals of crystallization process development and provides guidance for the design of a high quality crys...
Strategier för att kontrollera fördelning av kristallstorlek
I detta white paper behandlas strategier för att optimera fördelning av kristallstorlek under processutveckling och tillverkning.
Kristallisering
Industriell kristallisering är ett viktigt separations och reningssteg i kemiindustrin. Detta white paper visar hur inbyggd partikelteknik används för...
seeding crystallization process
Seeding is a key step in optimizing a crystallization process, ensuring a consistent filtration rate, yield, polymorphic form and particle size distri...
Scale-up of Batch Crystallization From Lab to Plant
Scale-up of crystallization is notoriously complicated and companies are under pressure to develop scalable crystallization processes faster - at lowe...
Best Practices for Crystallization Development
This white paper demonstrates the methodology chemists use to optimize critical crystallization parameters such as temperature profile, addition rates...
Partikelkarakterisering från småskaliga laboratoriereaktorer till fullskaliga produktionsrörledningar
Metoder för partikelstorleksanalys används för att effektivt leverera partikelprodukter av hög kvalitet. En kombination av offline-partikelstorleksan...

Webinars

Continuous Flow Chemistry Using PAT
Eric Fang of Snapdragon discusses how continuous flow chemistry is applicable across the entire value chain. Early implementation of continuous flow...
Eliminating Micronization Using Fine Particle Crystallization
Crystal engineering is applied when the crystal size distribution is too large to meet downstream specifications. By designing the crystallization to...
Calibration Free Supersaturation Assessment
The quantitative use of in situ ATR-FTIR for real time supersaturation assessment has been extremely well defined within the literature. However, thes...
metastable zone width (MSZW) crystallization
The webinar focuses on a semi-quantitative method for the optimization and scale-up of hydrodynamically limited anti-solvent crystallization process....
Improving Crystallization and Precipitation
This webinar introduces case studies and highlights best practices used to overcome crystallization and precipitation challenges. The focus will be on...

Citations

Crystallization and Precipitation Citation List
Crystallization and precipitation citation list and publications

Relaterade produkter

Technology For Using Antisolvent For Crystallization