A Raman spectrometer measures the vibrational modes of a sample using scattered light. In-situ Raman spectroscopy equipment furthers the technique and enables scientists to measure reaction and process trends in real time, providing highly specific information about reaction kinetics, polymorph transitions, mechanisms, and the influence of critical process parameters (CPP).
The ReactRaman™ 802L Raman spectrometer lets you directly track the concentration of solid and liquid reactants, intermediates, products, and crystal forms in situ to monitor changes throughout the experiment. Research, develop, and optimize reactions with information-rich experimentation to enrich process understanding.
An in-situ Raman spectrometer optimized for real-time analysis, coupled with an intuitive, integrated software platform, ensures reliable, high-quality reaction information from every experiment.
ReactRaman with iC Raman™ software brings compositional analysis to every lab from data collection to analysis. Automated parameter selection provides accurate data collection, enabling scientists to get confident results. Right first time, every time, in every process for every user.
In-situ Raman probe- and flow-based sampling technologies enable the study of liquid and solid phase chemistry in batch or continuous flow configurations. Fit-for-purpose process Raman probes allow use over a wide range of temperatures, pressures, and chemistries. Our Raman probe and optic options include:
To understand chemical reactions, chemists use Raman spectrometers to address the following:
Continuous monitoring with an in-situ Raman spectrometer allows you to trend components over time, making it easier to answer critical reaction and process optimization questions.
With safety interlocks and four visual indicators, you can work safely and easily identify when the laser is in use. ReactRaman and iC Raman will activate the laser only when all of the following interlock conditions are satisfied:
Class-leading performance with excellent stability and sensitivity in a compact, stackable package.
Deploy anywhere in the lab for batch or flow processes. A single robust connector guarantees alignment every time and inherent safety ensures worry-free measurements.
ReactRaman occupies little space and was designed to be stackable with other laboratory instruments for even more compact layouts.
Probe- and flow-based sampling technologies enable scientists to study liquid and solid phase chemistry in batch or continuous flow applications. Designed for purpose sampling options enable use over a wide range of temperatures, pressures, and chemistries.
Designed specifically for time-resolved reaction analysis, iC Raman™ software combines a peak picking algorithm with functional group intelligence to drastically reduce analysis time. Читать
As a company METTLER TOLEDO has over 30 years of experience dedicated to advancing reaction analysis. This is our focus and our passion. We built this expertise into our fit-for-purpose Raman spectrometers.
The ReactRaman spectrometer is part of an integrated family of products, which includes:
Designed specifically for chemical and process development, these tools are combined with iC Software Suite to provide comprehensive process understanding and control.
A Raman probe uses laser light to create a "fingerprint" by causing molecules in a sample to vibrate in a specific way when the light hits the sample. The fingerprint is then captured and sent via fiber optic cables to an analyzer, where it is compared to known signals. Raman probes use fibers to deliver the excitation laser beam to the sample and collect the signal, allowing for more flexibility with the sample holder.
These are for immersion, non-contact, and flow. The most common configuration is the immersion probe designed to be inserted into a reactor containing the reaction sample. If the chemistry is corrosive or needs to be sealed, using a non-contact Raman probe is often preferable outside of a site window looking into the reactor. The flow cell can be coupled in-line for flow applications to make continuous measurements.
Connect the Raman probe SmartConnector to the spectrometer base unit. Considering the type of sample to be measured, connect the sample interface end of the probe — an immersion probe into a reactor, a flow cell into a bypass loop or flow path, and a non-contact Raman optic at a site glass or window to remotely observe the reaction. Once the connection is complete, use iC Raman software to optimize the data acquisition parameters and set up the experiment profile.
A laser beam from the Raman analyzer is typically directed onto the sample, and the Raman scattered light is collected and returned to the spectrometer.
The resulting Raman spectrum, which represents the intensity of scattered light at different wavelengths, provides information about vibrations within the molecule and can be used to identify substances or study specific molecular interactions.
Raman spectrometers are used for identifying unknown materials and verifying or quantifying known materials. Raman spectroscopy is a non-destructive analysis technique that allows for fast and safe analysis, as no sample preparation is needed and, in some cases, samples can even be analyzed in their original packaging.
Applications of Raman spectroscopy include raw material verification, quality control of incoming goods, identification and analysis of active pharmaceutical ingredients (APIs), additives and excipients, and identification of illicit or counterfeit substances such as drugs.
More applications for laboratory Raman systems:
Handheld Raman systems are small, and lightweight, typically used for qualitative analysis and identifying unknowns in the field by comparing results against a stored spectral library.
Laboratory Raman systems such as ReactRaman offer better stability, higher resolution, and sensitivity compared to handheld Raman systems. Importantly, with the higher sensitivity of benchtop Raman systems, it is also possible to quantify substances at low concentrations.
Below is a selection of publications featuring in-situ Raman spectroscopy equipment: