Case Study: Point Of Use TOC Analysis

Continuous total organic carbon (TOC) measurement is relatively new in the pharmaceutical industry. Drug companies have been used to TOC analyzers that measure in fixed intervals of six minutes or longer. Pharmaceutical manufacturers need to tightly control their water system, and measurements every six minutes could miss TOC excursions.

With the new 6000TOCi analyzer from METTLER TOLEDO, rapid and continuous TOC measurement provides data to ensure excursions are never missed. Due to real-time TOC monitoring, full transparency and control of a water system can be demonstrated at all times.

A pharmaceutical manufacturer was looking for ways to achieve better control over the water system of their diabetes drug production line. The manufacturer opted for the continuous 6000TOCi analyzer from METTLER TOLEDO, instead of a batch-type analyzer.

Read in the case study how the pharmaceutical company was able to increase process transparency and reduce maintenance costs with continuous TOC measurement.

The 6000TOCi is METTLER TOLEDO Thornton’s total organic carbon analyzer for the pharmaceutical industry. Its rapid, continuous measurement provides data to ensure that excursions are never missed. This real-time TOC analyzer reports data every second for full transparency of TOC levels. Its unique hydro-mechanical design ensures measurement repeatability and stability over the lifetime of the instrument.

Proven UV technology and the highest accuracy conductivity sensors secure repeatable and precise measurements. The 6000TOCi is a solution with minimum complexity and eliminates many high-risk points of failure. Most importantly, it is compliant with all major global pharmacopeia for TOC with the necessary records to support audits.

The 6000TOCi features advanced Intelligent Sensor Management (ISM) diagnostics to safeguard effective TOC measurements. ISM is METTLER TOLEDO's process analytics platform that combines the advantages of on-line analytical measurements with modern digital technology to help ensure sensors do not fail during operation.