We offer a wide range of weighing solutions designed to meet the needs of the biopharmaceutical industry. METTLER TOLEDO balances will help you meet your needs thanks to their ability to be seamlessy integrated with third party systems resulting in error-free and efficient processes. Built on decades of METTLER TOLEDO weighing expertise, these balances will help you deliver reliable and precise results time and time again.
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Bioreactor control system with gravimetric feed is an efficient method for precise fermentation in biopharma applications. With the increasing need for accurate and consistent fermentation processes in the biopharmaceutical industry, the need for rapid, simple, compliant, and cost-efficient bioreactor process control becomes a key factor for success. A bioreactor feed control system based on adding liquids by weight rather than by volume is a proven method that ensures highly precise fermentation.
What Will You Learn with This Application Note?
This application note outlines how METTLER TOLEDO precision balances can control the flow of liquids into a bioreactor in a simple control loop involving the bioreactor, the pump and the balance. This control loop is established via seamless integration among the instruments. With gravimetric feed control using a balance, you can be sure of efficient, accurate, and reliable process control with a minimum amount of investment - resulting in more efficient research and development processes. Learn more about:
- Bioreactor control parameters
- Gravimetric feed control loops
- The best ways to control the liquid fill
- How to select the best balances for gravimetric feed control
Interested? Don’t hesitate to contact us at any time for expert advice and support. We want to ensure you have zero doubts when purchasing our equipment. This application note is focused on laboratory applications using laboratory balances. For larger scale applications, including those in production - please take a look at our high capacity industrial balances.
Balances for Biopharmaceutical Industry
Video: Why MS-TS Laboratory Balances Are Ideal for Gravimetric Feed Control Applications
MS-TS Laboratory Balances are an excellent choice for the biopharma industry for various reasons including:
- Seamless integration
- High performance
- Robust construction
- Simple operation
FAQs
What is the best laboratory balance for gravimetric feed control?
An easy integration of bioreactor, pump and balance is important. The MS-TS precision balance is the perfect choice thanks to integrated MT-SICS commands which allow for e.g. external reading of weighing results and seamless integration of the fermentation setup. Additionally, MS-TS precision balances are very reliable, easy to use and very robust. These balances are available with capacities from 320 g up to 12 kg and readabilities ranging from 1 mg up to 100 mg.
What are the advantages of gravimetric feed control over volumetric feed control?
Gravimetric feeding is considered the safest and most accurate method of regulating the flow of liquids into a bioreactor. The main advantage of gravimetric feed control is that this approach is much more precise and provides an easy and cost-effective way to monitor and control the weight loss of the feeding solution.
How can my bioreactor software read the weight values on my feeding bottles?
MS-TS balances have a wide set of MT-SICS commands that enable the balance to be controlled via appropriate PC software. In this way, the bioreactor software can communicate with the balance to read the weight remaining the feeding bottles and hence calculate the amounts that have been added to the bioreactor. The MT-SICS manual for your balance can be downloaded from the corresponding balance model page on our website., for example, the MT-SICS commands for the MS12002TS.
