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This white paper showcases the benefits of combining real-time FTIR spectroscopy (ReactIR) with kinetic modeling software (Reaction Lab and Dynochem) for chemical process development and optimization. The paper presents several case studies from pharmaceutical manufacturing illustrating how this approach improves process understanding, leading to increased efficiency, yield, safety, and scalability. Specific examples cover:
- Suzuki coupling reactions
- Curtius rearrangements
- SNAr couplings
- Hydrogenations
The use of in-situ data significantly reduces the need for traditional, resource-intensive experimental design, enabling faster and more sustainable process development. Finally, the paper highlights the software's user-friendly interface and its capabilities for model building, hypothesis testing, and process optimization.
