Application Note – Easier Sensor Sterility and Fewer Batch Losses

Maintaining batch integrity
Monitoring and controlling fermentation parameters in multiple benchtop bioreactors is a complex process that can be prone to errors. Occasional batch failure and subsequently, considerable resulting costs, are an unfortunate consequence. Even if a batch is not lost, incorrect analytical sensor readings can result in lower productivity due to the need to extend a run, additional downstream processing, or to reduced product quality.

Although modern pH sensors are designed to operate reliably in fermentation processes, exposure to high temperatures during sterilization and clean-in-place cycles will reduce a sensor's lifetime. To avoid pH sensors failing during fermentation, operators need to be sure they are fit for purpose or, at a high cost, new sensors need to be installed for every batch.

Advances in analytical sensor technology offer a new approach that minimizes the risk of batch contamination or loss.

Clever by design
Intelligent Sensor Management (ISM^®) uses the power of on-board microprocessors to provide worry-free sensor operations and maximum confidence in fermentation processes.

pH, dissolved oxygen and CO₂ sensors with ISM continuously monitor their own "health" and generate diagnostic tools that provide invaluable information for technicians and operators. These tools, such as the Dynamic Lifetime Indicator and CIP/SIP Counter clearly inform users if a sensor will perform reliably throughout a batch.   

Download the application note " Easier Sensor Sterility and Fewer Batch Losses" and find out how:

• Intelligent Sensor Management minimizes the risk of batch contamination and loss.
• Dissolved oxygen sensors with optical technology do not need polarization.
• ISM sensors can be calibrated away from the process and stored until required.
• And more…