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Roche's Innovative Approach to PAT Integration
This application note discusses a sustainable Process Analytical Technology (PAT) system using Process FTIR for the safe operation of a sodium borohydride reduction. Roche Ireland uses an innovative approach to PAT integration that bridges the gap between PAT and Quality Control, while further integrating PAT as a routine manufacturing system.
In-process Mid-IR was key in providing a solution to Roche's process problems. The goals for throughput, plant usage and manpower were achieved within a few weeks resulting in:
- Yield Improvement
- Zero Batch Failures
- Decrease From 8 Person Operation to 6 Person Operation
- Reduction in Manual Handling (Safety)
- Increase in Annual Profit