采用 FBRM 技术 的 ParticleTrack G400 是直接插入到实验室反应器中的探头式仪器,以便在全工艺过程浓度下实时追踪颗粒粒径及粒数变化。 随着实验条件的变化,持续监测颗粒、颗粒结构和液滴为科学家提供足够证据以获得具有所需属性的一致颗粒。
颗粒粒径与粒数直接影响多相工艺中的性能,包括结晶、乳化和絮凝。 通过实时监测颗粒粒径与粒数,科学家能够使用基于证据的方法自信地了解、优化和放大实验过程。
在为离线分析进行采样和制备时,颗粒可能发生变化。 通过追踪过程中自然存在的颗粒的粒径与粒数的变化,科学家能够安全且无延迟地了解工艺过程 – 甚至是在极端温度与压力条件下。
随着实验条件的变化,通过连续监测颗粒,能够确定过程参数对颗粒粒径和粒数的影响。 这种独特的信息可用于设计能够持续提供具有优化特性的颗粒的过程。
实验室中 ParticleTrack G400 的常见应用包括:
ParticleTrack G400 的主要特征:
ParticleTrack G400 比以前的梅特勒托利多 Lasentec FBRM 技术(S400 和 D600)有了重大改进。
测量范围 | 0.5 – 2000μm 0.5-2000um |
温度范围(主机/现场装置) | 5 至35°C |
主机说明 | 实验室主机 |
基座尺寸 (长x高x宽) | 492 mm x 89 mm x 237 mm |
认证 | CE 认证, 1 类激光, NRTL 认证, CB Scheme 认证 |
电源要求 | 100-240VAC, 50/60Hz, 1.2A |
适用于 | 实验室: EasyMax/OptiMax |
软件 | iC FBRM |
扫描系统 | 电子扫描仪 |
扫描速度 | 2m/s (19mm探头为1.2m/s) |
弦长选择方法(CSM) | Primary(精细)和 Macro(粗糙) |
探头直径 | 19mm探头 9.5mm 14/9.5mm |
探头浸湿长度 | 400mm (用于 19mm 探头) 206mm (用于 14/9.5mm 探头) 91mm (用于 9.5mm 探头) |
探头浸湿合金 | C22 |
测量视窗 | 蓝宝石 |
标准窗口封条 | Kalrez® (标准 19mm) TM(标准 14/9.5 ) TM(标准9.5,14/9.5) |
探头/窗口选件 | TM 窗口(用于19mm 探头的选件) |
额定压力(探头) | 高达 100barg (自定义) 3barg (标准) |
额定温度(探头) | +10 至 90°C (标准) -10 至 90°C (Kalrez 和清洗) -80 至 90°C (TM 和清洗) |
导管长度 | 3m [9.8ft] |
空气要求 | 清洗歧管的最大出口压力: 0.8barg [12psig] 清洗歧管的最大入口压力: 8.6barg [125 psig] 低流量清洗(使用以避免冷凝物) 最大 流量: 5NL/min [0.2SCFM] |
ParticleTrack型号 | ParticleTrack G400 |
除以上标准配置外,我们也可为您提供定制服务
具有 FBRM 技术的 ParticleTrack G400 未针对存在爆炸危险的位置进行评级。
ParticleTrack G400 represents a significant improvement over previous METTLER TOLEDO Lasentec FBRM technologies (S400 and D600).
Stuck Particle Correction Improves Consistent and Reliable Measurement - ParticleTrack can distinguish between particles stuck on the probe window and those moving in the process. These stuck particles can be removed from the data ensuring a consistent and reliable measurement for more experiments.
Improved Measurement Accuracy and Resolution - ParticleTrack uses state-of-the art digital signal processing methods to measure particle size with increased accuracy and resolution. These changes mean the measurement matches particle measurements such as laser diffraction and imaging more closely.
Wider Dynamic Range To Detect Critical Process Events - ParticleTrack measures changes in particle count to accurately eliminate concentration-related artifacts from the data and ensure improved sensitivity to changes in the particle system at higher concentrations. This allows critical process events to be detected that may previously have gone unobserved.
Interchangeable Probes Decrease Costs and Increase Range of Scales - Lab-based ParticleTrack instruments are now available with different sized probes that can be easily changed by the user. This improves serviceability and increases the range of scales where the same instrument may be used at an overall lower cost.
Two Measurements Acquired Simultaneously To Eliminate Need for Prior System Information or Trial Experimentation - ParticleTrack now collects two datasets simultaneously that are optimized for different types of particle systems. This eliminates the need for any a prior system information or trial experimentation to determine the optimal measurement method.
Improved Instrument to Instrument Repeatability - ParticleTrack technology was developed to ensure different lab and production instruments now measure much more closely, allowing changes in scale of measurement to be decoupled from differences in the probe used to measure them.
Voice of User
Senaputra, A., Jones, F., Fawell, P. D. and Smith, P. G. (2014), Focused beam reflectance measurement for monitoring the extent and efficiency of flocculation in mineral systems. AIChE J., 60: 251–265. doi: 10.1002/aic.14256.
"The [ParticleTracK]G400 also captures bimodal character in unweighted chord distributions, producing distinct peaks for aggregates and fines after suboptimal flocculation; such peaks are rarely well resolved in older FBRM".
"…the chord length measurement principle applied with the G400 probe leads to an enhanced sensitivity to species at the lower end of the measurement range relative to previous generation FBRM…"
"The mean square-weighted chord lengths reported from older generation FBRM for flocculated minerals are typically under 400 mm, and yet the naked eye can see much larger aggregates being formed in thickener feedwells. The G400 probe consistently measures larger chord lengths, and this is seen as a significant advantage"
George Zhou, Aaron J Moment, James F. Cuff, Wes A. Schafer,Charles Orella, Eric Sirota, Xiaoyi Gong, and Christopher J. Welch, Process Development and Control with Recent New FBRM, PVM, and IR. Org. Process Res. Dev., Just Accepted Manuscript, Publication Date (Web): 10 Jun 2014.
"Process analytical technologies (PATs) have played an important role in process development and optimization throughout the pharmaceutical industry. Recent new PATs, including in-process video microscopy (PVM), a new generation of focused-beam reflectance measurement (FBRM), miniature process IR spectroscopy, and a flow IR sensor, have been evaluated, demonstrated, and utilized in the process development of many drug substances. First, PVM has filled a technical gap by providing the capability to study morphology for particle engineering by visualizing particles in real time without compromising the integrity of sample. Second, the new FBRM G series has closed gaps associated with the old S series with respect to probe fouling, bearing reliability, data analysis, and software integration. Third, a miniaturized process IR analyzer has brought forth the benefits of increased robustness, enhanced performance, improved usability, and ease of use, especially at scale-up".