 |
This application note delves into the most effective conditions for running a chemical process by merging knowledge of kinetic and thermodynamic parameters, using the example of catalytic hydrogenation of aromatic nitro compounds. This chemical reduction process is critical for adding amino functionality to pharmaceutical and agrochemical intermediates, as well as in polyurethane chemistry. While hydrogenation of aromatic nitro compounds is generally easy with a variety of successful conditions, including vapor phase, it can be risky because of the creation of unstable hydroxylamine intermediates that can decompose and cause uncontrolled, dangerous temperature spikes, which could lead to an explosion.
This application note outlines the reduction of nitrobenzene using a commercially available catalyst that can generate any type of intermediate and by-product. The reaction was monitored by measuring the heat generated by the reaction, hydrogen consumption, and IR concentration profiles. This information was used to develop a comprehensive model that can accurately predict the scale-up behavior of a catalytic hydrogenation reaction.
Download this case study today for best practices to develop and optimize a safe and successful scale-up of catalytic hydrogenation.
