MSMPR Crystallizer

Improve Crystallization Experiments with Precise Control

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<center>Schematic design of a continuous MSMPR crystallization system</center>
Schematic design of a continuous MSMPR crystallization system
msmpr crystallizers for the lab
Continuous Manufacturing of Beta-Lactam Antibiotics
msmpr crystallizer with PAT integration

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FAQs

What is the difference between batch and continuous crystallization?

Batch and continuous crystallization are two different methods of producing solid materials, with batch crystallization being a discontinuous process that is controlled by adjusting various parameters and continuous crystallization being a continuous process that is controlled by adjusting feed rates and flow rates. Continuous crystallization is generally more efficient and produces more uniform crystals but requires specialized equipment. 

The main differences between batch and continuous crystallization are as follows:

  1. Process: Batch crystallization is a discontinuous process, meaning that the crystallization process is carried out in a single batch, starting with a liquid solution, then cooling or evaporating the solution to induce crystallization, and finally separating the crystals from the mother liquor. In contrast, continuous crystallization is a continuous process, meaning that the liquid solution is fed continuously into a crystallizer, and the crystals are continuously separated from the mother liquor.
  2. Control: In batch crystallization, the process is controlled by adjusting parameters such as temperature, concentration, and agitation, which can be difficult to maintain consistently from batch to batch. In contrast, continuous crystallization can be more easily controlled by adjusting the feed rate, flow rates, and residence time in the crystallizer, which can be monitored and adjusted in real time.
  3. Efficiency: Continuous crystallization is generally more efficient than batch crystallization because it can produce a higher yield of product in a shorter amount of time. Additionally, continuous crystallization can result in more uniform crystal sizes and shapes, which can be important for certain applications.
  4. Equipment: Batch crystallization typically requires larger vessels to accommodate the entire batch, while continuous crystallization can be performed in smaller vessels that can be scaled up or down as needed.

What is the difference between cooling and evaporative crystallization?

Cooling and evaporative crystallization are two common methods of separating solid materials from a liquid solution. Cooling crystallization involves cooling the solution to a temperature below the solute's saturation point, while evaporative crystallization involves heating the solution to evaporate the solvent and increase the solute concentration. The choice between the two methods depends on factors such as the solubility of the solute, the impurity content, and the required energy consumption.

 The main differences between cooling and evaporative crystallization are:

  1. Principle: Cooling crystallization is based on the principle that the solubility of a substance decreases as the temperature of the solution decreases. In this process, the liquid solution is cooled down to a point where the solute concentration exceeds its saturation point, leading to the formation of crystals. On the other hand, evaporative crystallization is based on the principle that the solubility of a substance decreases as the solvent's concentration decreases due to evaporation. In this process, the liquid solution is heated to evaporate the solvent, and, as the concentration of the solute in the solution increases, crystals start to form.
  2. Temperature: In cooling crystallization, the liquid solution is cooled to a temperature below the saturation point of the solute, which can be achieved by various cooling methods, such as heat exchangers or refrigeration systems. In contrast, in evaporative crystallization, the liquid solution is heated to increase the solute concentration until the solvent evaporates, leaving behind a concentrated solution that will eventually form crystals.
  3. Energy consumption: Cooling crystallization typically requires less energy than evaporative crystallization because the cooling process can be achieved using simple cooling methods. In contrast, evaporative crystallization requires more energy because the solvent must be evaporated, which requires additional heat input.
  4. Purity: Evaporative crystallization is generally more effective than cooling crystallization at separating impurities from the crystal product because the impurities are left behind in the concentrated solution that is removed during the evaporation process. In contrast, cooling crystallization is more likely to introduce impurities into the crystal product.

Which type of crystallizer is used most often in the pharmaceutical industry?

For pharmaceutical applications, MSMPR and plug flow reactors are used most often in order to achieve continuous manufacturing. Learn more about continuous flow chemistry.

There are several other types of crystallizers besides MSMPR, some of which are:

  • Continuous crystallizers: Operate in a continuous mode and are suitable for processes that require a large amount of product
  • Batch crystallizers: Operate in a batch mode and are suitable for processes that require a small amount of product
  • Cooling crystallizers: Rely on cooling to generate crystals and are used in processes where the product is highly soluble in the solvent
  • Evaporative crystallizers: Rely on evaporation to generate crystals and are used in processes where the product is not highly soluble in the solvent
  • Vacuum crystallizers: Operate under vacuum conditions and are used in processes where the product is heat-sensitive
  • Swirl tube crystallizers: Use a rotating tube to create a swirling flow of supersaturated solution, which promotes crystal growth
  • Draft tube baffle crystallizers: Use a draft tube and a series of baffles to control crystal growth and promote crystal size uniformity
  • Fluidized bed crystallizers: Suspend the crystals in a fluidized bed to promote crystal growth and prevent agglomeration
  • Spouted bed crystallizers: Use a spouted bed to promote crystal growth and prevent agglomeration