Easy Automated Standard Preparation

Optimize Your Time, Your Methods and Your Workflows

The manual process of developing, optimizing and validating methods ends up being the most time-consuming part of the analytical workflow. Out of Specification (OOS) and Out of Trend (OOT) errors might occur and are likely to affect the entire analysis, as an accurate standard preparation is crucial for the quality of the final result.

Weighing automation is the perfect solution to these problems. The automated weighing and dispensing of both powders and liquids allows you to achieve the right concentration every time, helping you to work efficiently and to avoid errors and potential rework.

Read our application note to discover the benefits of automated powder and liquid dispensing with the XPR Automatic Balance. Learn about quick and easy ways to prepare accurate reference standards for HPLC and other chromatographic (analytical) methods. The method enables using less substance and solvent, ultimately significantly saving time and money.

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Types of Reference Standards

Reference standards are used to identify or determine the concentration of an analyte in a sample of unknown concentration. The reference standard is prepared with a known concentration, so the unknown sample can be compared to it, in order to determine the actual concentration of the sample. There are two different types of standards:

 

Internal StandardsExternal Standards
Added to the unknown sample and analyzed at the same timeAllows highly accurate monitoring of the compounds based on residence time
Used for calibration, by simply plotting the ratio of the analyte signal to the internal standard signal, as a concentration functionUsed for calibration by preparing various concentrations of the external standard, and creating a calibration graph
Allows highly accurate monitoring of the compounds on the basis of residence timeUsed to determine the exact concentration of a compound in the sample

 

Note: Some companies refer to reference standards that were purchased from other companies as external standards, while standards from within the company are then called internal standards.