High value chemicals must meet rigorous standards for quality and effectiveness and they must be delivered reliably - where and when they are needed. This must be accomplished while making every effort to responsibly lower costs. Scientists must design processes that create highly manufacturable products while reducing the complexity and cost of each step. The references and resources below describe how scientists from R&D to manufacturing work together to reach this goal.
Ce webinaire aborde l'importance du mélange et compare le mélange en laboratoire et le mélange à grande échelle. La présentation comprend des extraits de deux courtes balances données par Reinaldo Machado, intitulées Fundamentals of Scale-up et iControl Mixing Guidelines.
David Ford of Nalas investigated an Oxidative Nitration reaction with a fast and highly exothermic oxidation step using reaction calorimetry and Process Analytical Technology (PAT).
This webinar focuses on how to improve process development and scale-up by leveraging calorimetry and in situ process analysis. In order to provide the best possible customer service, Lubrizol redefined traditional process development to reduce the time and complexity of new product development, and scale-up/scale-down optimization.
Cette présentation explique comment une installation réussie de la technologie FTIR in situ dans l'environnement de production peut être réalisée en suivant un protocole appelé ACES (Application, Communication, Environnement, Échantillonnage).
Les réactions chimiques exothermiques présentent des risques inhérents, et ce tout particulièrement au cours de l'extrapolation. Des études publiées par de grandes entreprises chimiques et pharmaceutiques ont révélé que les réactions de Grignard exothermiques peuvent être extrapolées en toute sécurité du laboratoire de développement jusqu'au processus de fabrication, en suivant quatre étapes clés.
Real-time monitoring of crystallization is shown to provide benefits leading to improved methods for process development, optimization and scale-up. This white paper reviews case studies examining many of these benefits for: - Providing process knowledge that enables real improvements in yield, throughput and profitability of production scale crystallization - Eliminating downstream bottlenecks by improving filtration/dryer performance - Accelerating the characterization of critical operating parameters for increased productivity - Enabling the design of more robust processes to assure batch-to-batch repeatability and consistent meeting of crystal specifications - Identifying undesired events in real time to help ensure product quality
Lab to Plant Challenges