Improving Cell Culture Process Control While Maintaining Quality of Biologics

Speaker information

Olivier R. Berteau is Global Pharmaceutical Industry Manager at Mettler-Toledo Ingold. With a chemical engineering background, he started his career working for the defense industry and from this period (early 90's); he became interested in the design of PODs and the design of modular systems. From 1992 with the monitoring and guidance of Professor Henri Blachere, he designs, develops and works intensively with different bioreactor and fermenter manufacturers. Since that time, he has been involved in the development and strategic NPI initiatives for several technologies for bioprocessing: Hemoglobin as an oxygen transporter for cell culture, multi-sensor (5 parameters) in a 25 mm peak sphere moving freely in a bioreactor, capacitance sensors, fully automated fermentation at mini scale (BioPOD) and finally acoustic single use perfusion to name only the essentials. It was in 2003 while continuing to apply the concept of POD that he began to take an interest in the concepts of continuous manufacturing, drawing inspiration from a 1971 patent demonstrating the performance of continuous cultures of yeast for more than 9 months without inducing cross-contamination. In 2013, before joining METTLER TOLEDO, he has patented a method in cell culture using scale-out concepts under perfusion. Olivier represents 25+ years of hands-on operating experience within the biopharmaceutical industry with expertise in technology, technology development and product development for upstream bioprocessing applications.