The Changing Role of PAT in Scale-up
Bridging the Gaps From Process Development to Commercialization
The role of Process Analytical Technology (PAT) differs drastically when it is used for development, scale-up or production purposes. With such varying roles, changes in the number of techniques and frequency of use are often observed.
In the presentation, "The Changing Role of PAT From Process Development to Commercialization and Bridging the Gaps Between Them", Jan Dijkmans of Janssen, describes the differences and presents examples for each of these roles.
Topics include:
- The use of PAT from lab to plant
- PAT to verify or deny correct scale-up
- Process fingerprinting
- Recent advances on how to bring PAT data from the lab into the plant for live verification and analysis during scale-up
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About the Presenter
Jan Dijkmans, Ph.D.
Janssen
Jan obtained his Master's degree in Bioscience Engineering from the University of Leuven, Belgium. He then joined the group of Professor Bert Sels where he developed heterogeneous catalysts for Biomass conversion to chemicals, focusing on incorporation of Sn into zeolite structures. He received his Ph.D. in Bioscience Engineering in 2015. After a one-year post-doc project collaborating with Total Petrochemicals, Jan joined Janssen Pharmaceuticals (Johnson & Johnson). In his role as Process Engineer, he develops robust processes, using a combination of data-rich experimentation, modelling, data analysis and technology. He is the department's PAT subject matter expert. In this role, he supports colleagues when performing or analyzing PAT experiments and improves the implementation of the technologies during development and scale-up of processes.
