High value chemicals must meet rigorous standards for quality and effectiveness and they must be delivered reliably - where and when they are needed. This must be accomplished while making every effort to responsibly lower costs. Scientists must design processes that create highly manufacturable products while reducing the complexity and cost of each step. The references and resources below describe how scientists from R&D to manufacturing work together to reach this goal.
Deze webinar legt uit wat het belang van mengen is en vergelijkt mengen in het lab met mengen op grote schaal. De presentatie is een samenvatting van twee korte trainingen die worden gegeven door Reinaldo Machado over de fundamentele principes van opschaling en de iControl mengrichtlijnen.
David Ford of Nalas investigated an Oxidative Nitration reaction with a fast and highly exothermic oxidation step using reaction calorimetry and Process Analytical Technology (PAT).
This webinar focuses on how to improve process development and scale-up by leveraging calorimetry and in situ process analysis. In order to provide the best possible customer service, Lubrizol redefined traditional process development to reduce the time and complexity of new product development, and scale-up/scale-down optimization.
This presentation discusses how a successful installation of in situ process FTIR technology in the production environment can be achieved by following a protocol called ACES (Application, Communication, Environment, Sampling).
Exotherme chemische reacties houden risico's in, zeker bij opschaling. Gepubliceerde onderzoeken van top chemie en farmaceutische bedrijven laten zien dat door de volgende vier essentiële stappen, exotherme Grignard reacties veilig opgeschaald kunnen worden, zowel in het lab als in de productie.
Real-time controle van kristallisatie levert voordelen die zorgen voor betere methodes voor procesontwikkeling, optimalisatie en opschaling.
Lab to Plant Challenges