Seminar

pH Control in Biopharma

Why It's More Important Than Ever

Program Overview

  • The critical role of in-line pH sensors in lean biomanufacturing
  • Essential sensor enhancements to measurement reliability
  • Digitization and predictive sensor diagnostics

Higher Productivity, Greater Yield 

Since the inception of biomanufacturing with the advent of recombinant technology in the 1970s, bioprocessing engineers have recognized that pH measurement and control are paramount for process analytical technology pertaining to cellular processes. Aimed at maximizing both productivity and product yield, it soon became evident that the same principles apply to the downstream processing operations involved in the purification of the final product.

Consequently, the in-line real-time combination pH probe has emerged as an indispensable measurement tool within the biomanufacturing environment. The demand for precise and reliable pH measurement and control has only intensified since that time. In this webinar, we will explore the critical role of the in-line pH sensor and its significance in relation to lean biomanufacturing principles. Additionally, we will examine several essential enhancements to measurement reliability, including signal digitalization, drift and offset mitigations, and improved pH glass sensitivity.


Speakers

Ehsan photo

Dr. Ehsan Mahdinia

METTLER TOLEDO Process Analytics

Ehsan holds a Ph.D. in Microbiological Engineering awarded by the Agricultural and Biological Engineering Department of the Pennsylvania State University. He holds a Master’s Degree in Biotechnology from the Department of Chemical and Petroleum Engineering of the Sharif University of Technology in Tehran, Iran. Previously, he was Director of the Masters of Biomanufacturing & Bioprocessing program at the Stack Family Center for Biopharmaceutical Education & Training (CBET), where he also helped lay the foundation as one of the founding faculty members for CBET. Ehsan simultaneously served as an Assistant Professor at the Departments of Basic & Clinical Sciences and Pharmaceutical Sciences at the Albany College of Pharmacy and Health Sciences. Dr. Mahdinia also worked as Associate Editor for the Journal of Molecular Biotechnology-Springer.