High value chemicals must meet rigorous standards for quality and effectiveness and they must be delivered reliably - where and when they are needed. This must be accomplished while making every effort to responsibly lower costs. Scientists must design processes that create highly manufacturable products while reducing the complexity and cost of each step. The references and resources below describe how scientists from R&D to manufacturing work together to reach this goal.
This webinar discusses the importance of mixing and compares lab mixing and large scale mixing. The presentation features excerpts from two short courses given by Reinaldo Machado entitled Fundamentals of Scale-up and iControl Mixing Guidelines.
David Ford of Nalas investigated an Oxidative Nitration reaction with a fast and highly exothermic oxidation step using reaction calorimetry and Process Analytical Technology (PAT).
This webinar focuses on how to improve process development and scale-up by leveraging calorimetry and in situ process analysis. In order to provide the best possible customer service, Lubrizol redefined traditional process development to reduce the time and complexity of new product development, and scale-up/scale-down optimization.
This presentation discusses how a successful installation of in situ process FTIR technology in the production environment can be achieved by following a protocol called ACES (Application, Communication, Environment, Sampling).
Exothermic chemical reactions pose inherent risks – especially during scale-up. Published studies from top chemical and pharmaceutical companies show that by following four key steps, exothermic Grignard chemistry can be safely scaled-up from bench to manufacturing.
Scale-up of crystallization is notoriously complicated and companies are under pressure to develop scalable crystallization processes faster - at lower costs and with higher quality. Real-time monitoring of crystallization is shown to provide benefits leading to improved methods for process development, optimization, and scale-up.
Lab to Plant Challenges