Risks From Rising Temperature
In chemical process scale-up, understanding temperature change and the associated heat that is accumulated by the reaction are critical to process safety.
Process Development of Organosilicon Flame Retardants
Mike DiPierro, John Gohndone, and Brian Deeth discuss the process development of organosilicon flame retardants at Dow Performance Silicones.
This webinar includes practical examples and case studies from Dow Performance Silicones. Join the over 500 researchers who have already viewed this presentation.
Dow Performance Silicones developed a process for a new silicon-based, halogen-free flame retardant. The production process of organosilicon flame retardants requires careful control of an exothermic reaction. In situ FTIR spectroscopy and reaction calorimetry were used for the process development. In situ FTIR spectroscopy helped to understand how different parameters affect the reaction rate and chemical structure. The real-time monitoring capability helped avoid accumulation of energetic reactants and mitigated the risk of a run-away reaction. Reaction Calorimetry was used to gather additional information about the reaction, including:
- Heat of Reaction
- Temperature Effects
- Initiation Behavior
Using advanced process analytical tools, a large amount of information was gathered with just a few carefully planned experiments, and a safe, scalable process was developed.
Who Should View This Presentation?
Chemical Engineers and Chemists in Pharmaceutical and Chemical Industries as well as Academia.
Guest Presenters
Mike DePierro works in the Process R&D group within the Dow Performance Silicones Business. He has been involved with several organosilane process development projects since joining Dow Corning. He leads the Process Chemistry Community of Practice for the Dow Performance Silicones business and recently led the Specialty Siloxanes Tech Center program, contributing to expansion of several organosiloxane products. Prior to joining Dow Corning, he was employed with General Electric and Sabic Innovative Plastics with different roles in process and product development. He completed a PhD in Chemical Engineering at the University of Iowa.
Mike DePierro - Dow Corning
John Gohndrone - Dow Corning Corporation
Dr. John Gohndrone is a Process Research and Development Fellow with The Dow Chemical Company. He has 31 years of experience focused on the development, scale-up, implementation, and improvement of process technology for organofunctional silanes and silicones. During the past 20 years Dr. Gohndrone has been involved in developing of a number of phase-transfer-catalysis (PTC) processes for the production of organofunctional silanes and has 7 patents and several publications related to PTC process technology. Before joining The Dow Chemical Company, Dr. Gohndrone worked for Dow Corning Corporation since 1987. He received a B.S. degree in chemical engineering from the Illinois Institute of Technology and a M.S and PhD in Chemical Engineering from the University of Illinois at Champaign-Urbana.
Brian Deeth is currently a Senior Process Research and Development Scientist with The Dow Chemical Company. He has over 30 years industrial experience with over 20 years in Process R&D for silicone organic hybrid materials. Brian’s professional background also includes analytical chemistry and evaluation of reactive chemical hazards. Prior to joining Dow Chemical in 2016, Brian was employed by Dow Corning Corporation. He earned a B.S in Chemistry from University of Wisconsin at La Crosse.
Additional Process Safety Resources
Safe Handling of Hydrogen Peroxide
5-Bromo-2-nitropyridine was prepared from the corresponding amine via hydrogen peroxide oxidation in large scale production. Initially, this transformation showed low conversion, high impurity content and lack of reproducibility in lab trials. Parallel to process development, safety studies were conducted to investigate the stability of oxidant mixture, its composition and the oxidation reaction itself by reaction and adiabatic calorimetry. The resulting robust reaction conditions and appropriate safety boundaries allowed to develop a reproducible, safe protocol for the implementation of this chemistry on large scale, obtaining consistent results throughout the campaign.
Process Safety for 1M BTHF in the Plant
Alex Monteiro of GlaxoSmithKline discusses process safety considerations for the use of 1 M borane tetrahydrofuran complex under general purpose plant conditions. View case studies and practical examples of how GlaxoSmithKline ensures safety in the plant.