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Maintaining batch integrity
Monitoring and controlling fermentation parameters in multiple benchtop bioreactors is a complex process that can be prone to errors. Occasional batch failure and subsequently, considerable resulting costs, are an unfortunate consequence. Even if a batch is not lost, incorrect analytical sensor readings can result in lower productivity due to the need to extend a run, additional downstream processing, or to reduced product quality.
Although modern pH sensors are designed to operate reliably in fermentation processes, exposure to high temperatures during sterilization and clean-in-place cycles will reduce a sensor's lifetime. To avoid pH sensors failing during fermentation, operators need to be sure they are fit for purpose or, at a high cost, new sensors need to be installed for every batch.
Advances in analytical sensor technology offer a new approach that minimizes the risk of batch contamination or loss.
Clever by design
Intelligent Sensor Management (ISM®) uses the power of on-board microprocessors to provide worry-free sensor operations and maximum confidence in fermentation processes.
pH, dissolved oxygen and CO2 sensors with ISM continuously monitor their own "health" and generate diagnostic tools that provide invaluable information for technicians and operators. These tools, such as the Dynamic Lifetime Indicator and CIP/SIP Counter clearly inform users if a sensor will perform reliably throughout a batch.
Download the application note " Easier Sensor Sterility and Fewer Batch Losses" and find out how:
- Intelligent Sensor Management minimizes the risk of batch contamination and loss.
- Dissolved oxygen sensors with optical technology do not need polarization.
- ISM sensors can be calibrated away from the process and stored until required.
- And more…
