To understand the importance of PAT in biotechnology, it is first essential to understand the existing types of analytical processes:

Offline monitoring

Offline monitoring

Offline measurements require the collection of a sample, which is taken to a lab to be analyzed.

At-line measurements

At-Line measurements

At-line measurements are at the side of the process but are not directly integrated. The sample has to be actively removed and delivered to the analytical method. 

In-Line analysis

In-Line analysis

In-Line analysis uses sensors placed in the process vessel to conduct in situ measurements. 

Online monitoring

Online monitoring

Online sensors are placed on a side stream of the process and measured continuously.

Since they are built on a bypass, there will be a delay in the reported measurement versus in-line. 

Analytical Sensors for Bioreactors

Analytical Sensors for Bioreactors

METTLER TOLEDO produces in-line analytical sensors for monitoring and controlling key analytical par...

dynochem biologics

Dynochem Biologics

Fit-for-purpose simulation software to support bioprocessing upstream and downstream unit operations...

automated-reactor

Automated Lab Reactors and In-Situ Analysis

Particle size analyzers, FTIR and Raman spectrometers, chemical synthesis reactors, reactor control...

CytoDirect automated cell counting used in the biolab under the hood

Cell Analysis

METTLER TOLEDO now offers CytoDirect, an automated stain-free cell counter, ensuring a consistent nu...

Industrial Scales and Weighing Scales

Industrial Weighing Scales and Systems

Bench Scales, Portable Scales, Floor Scales, Counting and Mixing Scales, Terminals, Weigh Modules, L...

METTLER TOLEDO Service is your one-stop shop for all your balance service, scale service, and inspection device service needs. From installation and initial calibration to preventive maintenance and timely upgrades, we ensure your operations run smoothly and efficiently.
Measure with Confidence and Accuracy

Calibration and Certificates

Achieve and maintain compliance through consistent procedures and adhere to local and global regulations and standards, such as:

1
ISO 17025
2
EURAMET
3
USP, GLP and GMP
4
NIST Handbook 44 and OIML
5
Measuring Instruments Directive (MID)
In Compliance with Your Quality System and Regulatory Standards

Equipment Qualification

Ensure a perfect start and ongoing, worry-free use with immediate and long-term benefits:

1
Assurance that the equipment is fit for use
2
Cost-savings through manufacturer's qualification services
3
Confidence that the equipment meets process requirements
4
Identification of needed calibration and maintenance
Boost Your Performance with Equipment Maintenance

Preventive Maintenance

Pre-plan your periodic maintenance that provides you with complete trust that your equipment achieves:

1
Consistent, accurate results
2
Safe and reliable operation
3
Optimal performance possible
4
A longer equipment lifespan, resulting in a higher ROI