Dynochem Biologics™ is bioprocess simulation software specifically designed to empower biochemists and biochemical engineers. It tackles upstream and downstream unit operations, allowing you to optimize your processes at any scale.
Common applications of Dynochem Biologics are ensuring mixing equivalence (power per unit mass, mixing time, and mass transfer rate) in scale-down experiments in vials, shake flasks, wave bags, and Ambr 15® cell culture bioreactor systems to replicate full-scale operations or in scale-up to single-use or tall tank bioreactors.
Dynochem Biologics provides users with template models for typical mAb purification steps such as tangential flow filtration, chromatography, and other bioprocess downstream operations.
Delivered with extensive training and expert user support on projects, Dynochem Biologics is designed to be widely deployed to biochemists and biochemical engineers who are not experts in simulation and use of modeling tools but see the value in this approach to help decision-making, speed process development and ensure right first time scale-up.
Leverage models to understand the impact of critical process parameters on key quality attributes at multiple scales.
For example, ensure equivalent mixing performance between shake flasks, wave bags, Ambr® 15 reactors, and production bioreactors.
Mixing calculation tools helps scale from common lab-scale reactors to large-scale biologics reactors.
Dynochem Biologics Resources provides a full library of models for common upstream and downstream operations. The easy-to-use interface, coupled with training from modeling experts, enables roll-out to a wide user base.
Dynochem Biologics template models include:
Process analytical technology (PAT) is a manufacturing methodology for high-value chemicals and pharmaceuticals.
Critical parameters (CPPs) and key performance indicators (KPIs) of the process are thoroughly understood, well-defined, and continually monitored in order to ensure that the pre-defined critical quality attributes (CQA) of the final product are consistently achieved.
Data from process analytical technology (PAT) enables detailed models, making it possible to design and analyze fewer high-quality experiments to characterize and successfully scale your bioprocess system.
With Dynochem Biologics, you get access to our full Knowledge Base with a wealth of content including:
Free training sessions are also available so you get the most out of your software.
Reaction Lab was designed to integrate seamlessly with in-situ probes, including the EasySampler automated sampling system, ReactIR FTIR spectrometers, ReactRaman Raman spectrometers, as well s offline techniques such as HPLC and NMR. The consolidated data stream of reaction parameters together with information on kinetics, reaction mechanisms, impurity profiles, and particle attributes provides critical answers when adapting lab processes to the plant. The integrated solution enables scientists to deliver life-changing products faster and more cost-efficiently.
Dynochem Biologics captures decades of fluid mixing knowledge and contains an integrated database of your equipment to perform rapid and accurate mixing assessments, including mass transfer, mixing time, power input, and shear. Users can also characterize equipment using their data.
Users can characterize and optimize cell growth, nutrient uptake, titer, and metabolite concentration for upstream applications, including oxygen transfer, carbon dioxide stripping, and pH level.
For downstream applications, users can develop custom models or choose from the library covering harvest, depth filtration, chromatography, viral inactivation, TFF, UF/DF (including gel polarization), and lyophilization.
Similar tools are included for ancillary operations such as media and buffer preparation operations.
Predict, optimize, and scale critical unit operations using digital twins that leverage your process and analytical data and combine it with institutional knowledge. For example:
