Design of Experiment studies facilitate fast and efficient discovery and development of new chemical entities, which was an ongoing challenge. Organic chemists and engineers apply various techniques and methods to improve synthetic pathways, so that they become more effective and minimize the consumption of precious starting material. Advancements in synthesis methods and tools have made improvements possible.
In synthetic organic chemistry labs, obstacles or constraints still surface and need to be resolved. A chemical reaction is affected by multiple parameters, making it difficult to find optimal parameters quickly and efficiently. Chemistry can be influenced by parameters including concentration, addition rate, temperature, the solvent, catalyst and pH. Frequently, parameters influence each other. Reactions may also be affected by the stirrer type and speed, which impact the mass transfer and further influence the result of the experiment.
Rather than adopting a "trial-and-error" approach, where each parameter is examined individually and interactions between them cannot easily be detected, scientists can apply the Design of Experiments (DoE) methodology in the synthetic organic chemistry lab. A white paper describes the DoE approach and how it is used to identify the relationship between parameters, defining optimal settings at which the response variable (including yield, selectivity, impurity level) reaches the ideal value.
Two Design of Experiment (DoE) case studies are presented:
Denne hvitboken tar for seg et nytt verktøysett spesielt utformet for kjemikere, som utvider de eksperimentelle alternativene, automatiserer langtekkelige arbeidsoppgaver og registrerer data av høy kvalitet med ett tastetrykk.
Learn how Design of Experiments (DoE) is applied to chemical synthesis at Lonza Peptide.
Advances in organic chemistry allow researchers to expand R&D of molecules and optimize process conditions. A new white paper presents 4 case studies where pharma companies implement new synthesis techniques.
Design of Experiments (DoE) requires experiments to be conducted under well-controlled and reproducible conditions in chemical process optimization. Chemical synthesis reactors are designed to perform DoE investigations ensuring high quality data.
