ParticleTrack G400 con tecnología FBRM es un instrumento basado en sensores que se inserta directamente en reactores de laboratorio para hacer un seguimiento en los cambios del tamaño y el recuento de las partículas en tiempo real en concentraciones completas del proceso. Las partículas, las estructuras de partículas y las gotas se controlan constantemente a medida que las condiciones de los experimentos varían, ofreciendo a los científicos las pruebas necesarias para suministrar partículas uniformes con las características precisas.
El tamaño de las partículas y el recuento influyen directamente en las prestaciones de procesos multifásicos, incluidas la cristalización, la emulsificación y la floculación. Al controlar el tamaño de las partículas y el recuento en tiempo real, los científicos pueden comprender, optimizar y escalar los procesos de forma fiable usando métodos basados en pruebas.
Las partículas pueden variar cuando se muestrean y preparan para el análisis fuera de línea. Cuando se realiza el seguimiento de los cambios en el tamaño y el recuento de la forma en la que las partículas existen naturalmente en el proceso, los científicos comprenden el proceso de modo seguro y sin retrasos, incluso a temperaturas y presiones extremas.
Al monitorizar las partículas de forma continua a medida que los parámetros del experimento varían, resulta posible determinar la influencia de los parámetros del proceso relativos al tamaño y al recuento de las partículas. Esta información única se puede usar para diseñar procesos que proporcionan partículas con características optimizadas de forma uniforme.
Las aplicaciones comunes para ParticleTrack G400 en el laboratorio incluyen:
Funciones clave de ParticleTrack G400:
ParticleTrack G400 supone una mejora considerable en relación con las tecnologías METTLER TOLEDO Lasentec FBRM anteriores (S400 y D600).
Insert ParticleTrack probes directly into process streams to monitor particle size and count continuously over time without having to take a sample.
What is Focused Beam Reflectance Measurement (FBRM) technology?
Intervalo de medición | 0,5 – 2.000 μm |
Intervalo de temperatura (unidad de campo/base) | 5 a 35 °C |
Descripción de la unidad base | Unidad base de laboratorio |
Dimensiones de la unidad base (LxAxA) | 492 mm x 89 mm x 237 mm |
Certificaciones | Aprobación CE, clase 1 láser, certificación NRTL, certificación esquema CB |
Requisitos de alimentación | 100-240 V CA, 50/60 Hz, 1,2 A |
Para uso en | Laboratorio EasyMax/OptiMax |
Software | iC FBRM |
Sistema de barrido | Escáner eléctrico |
Velocidades de barrido | 2 m/s (19 mm a 1,2 m/s) |
Método de selección de cuerda (CSM) | Primario (preciso) Y Macro (aproximado) |
Diámetro del sensor | 19 mm 9,5 mm 14/9,5 mm |
Longitud del sensor húmedo | 400 mm (para sensor de 19 mm) 206 mm (para sensor de 14/9,5 mm) 91 mm (para sensor de 9,5 mm) |
Aleación del sensor húmedo | C22 |
Ventana | Zafiro |
Sellos de la ventana estándar | Kalrez® (estándar 19 mm) TM (estándar 14/9,5) |
Opciones de ventana/sensor | Ventana TM (opción para 19 mm) |
Índice de presión (sensor) | hasta 100 barg (personalizado) 3 barg (estándar) |
Intervalo de temperatura (sensor) | +10 a 90 °C (estándar) -10 a 90 °C (Kalrez y purgado) -80 a 90 °C (TM y purgado) |
Longitud del conducto | 3 m [9,8 ft] |
Requisitos de aire | Máx. presión de salida para purgar colector: 0,8 barg [12 psig] Máx. presión de entrada para purgar colector: 8,6 barg [125 psig] Purgado de caudal bajo: (usar para evitar condensación) Caudal máx.: 5 NL/min [0,2 SCFM] |
Modelo ParticleTrack | ParticleTrack G400 |
ParticleTrack G400 with FBRM Technology is not rated for explosive locations.
ParticleTrack G400 represents a significant improvement over previous METTLER TOLEDO Lasentec FBRM technologies (S400 and D600).
Stuck Particle Correction Improves Consistent and Reliable Measurement - ParticleTrack can distinguish between particles stuck on the probe window and those moving in the process. These stuck particles can be removed from the data ensuring a consistent and reliable measurement for more experiments.
Improved Measurement Accuracy and Resolution - ParticleTrack uses state-of-the art digital signal processing methods to measure particle size with increased accuracy and resolution. These changes mean the measurement matches particle measurements such as laser diffraction and imaging more closely.
Wider Dynamic Range To Detect Critical Process Events - ParticleTrack measures changes in particle count to accurately eliminate concentration-related artifacts from the data and ensure improved sensitivity to changes in the particle system at higher concentrations. This allows critical process events to be detected that may previously have gone unobserved.
Interchangeable Probes Decrease Costs and Increase Range of Scales - Lab-based ParticleTrack instruments are now available with different sized probes that can be easily changed by the user. This improves serviceability and increases the range of scales where the same instrument may be used at an overall lower cost.
Two Measurements Acquired Simultaneously To Eliminate Need for Prior System Information or Trial Experimentation - ParticleTrack now collects two datasets simultaneously that are optimized for different types of particle systems. This eliminates the need for any a prior system information or trial experimentation to determine the optimal measurement method.
Improved Instrument to Instrument Repeatability - ParticleTrack technology was developed to ensure different lab and production instruments now measure much more closely, allowing changes in scale of measurement to be decoupled from differences in the probe used to measure them.
Voice of User
Senaputra, A., Jones, F., Fawell, P. D. and Smith, P. G. (2014), Focused beam reflectance measurement for monitoring the extent and efficiency of flocculation in mineral systems. AIChE J., 60: 251–265. doi: 10.1002/aic.14256.
"The [ParticleTracK]G400 also captures bimodal character in unweighted chord distributions, producing distinct peaks for aggregates and fines after suboptimal flocculation; such peaks are rarely well resolved in older FBRM".
"…the chord length measurement principle applied with the G400 probe leads to an enhanced sensitivity to species at the lower end of the measurement range relative to previous generation FBRM…"
"The mean square-weighted chord lengths reported from older generation FBRM for flocculated minerals are typically under 400 mm, and yet the naked eye can see much larger aggregates being formed in thickener feedwells. The G400 probe consistently measures larger chord lengths, and this is seen as a significant advantage"
George Zhou, Aaron J Moment, James F. Cuff, Wes A. Schafer,Charles Orella, Eric Sirota, Xiaoyi Gong, and Christopher J. Welch, Process Development and Control with Recent New FBRM, PVM, and IR. Org. Process Res. Dev., Just Accepted Manuscript, Publication Date (Web): 10 Jun 2014.
"Process analytical technologies (PATs) have played an important role in process development and optimization throughout the pharmaceutical industry. Recent new PATs, including in-process video microscopy (PVM), a new generation of focused-beam reflectance measurement (FBRM), miniature process IR spectroscopy, and a flow IR sensor, have been evaluated, demonstrated, and utilized in the process development of many drug substances. First, PVM has filled a technical gap by providing the capability to study morphology for particle engineering by visualizing particles in real time without compromising the integrity of sample. Second, the new FBRM G series has closed gaps associated with the old S series with respect to probe fouling, bearing reliability, data analysis, and software integration. Third, a miniaturized process IR analyzer has brought forth the benefits of increased robustness, enhanced performance, improved usability, and ease of use, especially at scale-up".