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Validation of titration methods guide |
The quality of your product depends on the analyses performed in quality control. A detailed method is compiled and applied in order to obtain correct results. By validating the analytical methods an important step is taken in achieving this goal.
This guide addresses analysts from regulated laboratories in the various industries. It provides not only an explanation of important validation parameters but also gives details of strategies and specific recommendations for titration methods. In this document you will also find universal protocols for method development explained by means of common titration applications. Six different titration methods are validated in the examples:
- The determination of sulfuric acid by acid/base titration
- The determination of chloride by precipitation titration
- The determination of water content by Karl Fischer titration
- The determination of residual chlorine by potentiometric titration
- The determination of alkalinity by potentiometric titration
- The determination of total hardness by photometric titration
Besides the method validation, another important and supplementary approach in delivering trustworthy and reliable analytical data is the accomplishment of the results with the confidence interval. This document covers the four steps to calculate the measurement uncertainty of results.
