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Maintaining precise pH control is crucial for the safety and effectiveness of pharmaceutical products, especially aqueous liquid medications. The pH level affects drug availability, biological functions, microbial activity, and chemical stability. Therefore, strict specifications and testing methods are essential to ensure these products are safe and effective. Measuring the pH of suspensions can be challenging due to the dispersed or particulate nature of samples and particle-induced sensor clogging, which affects measurement accuracy and sensor lifespan. To overcome these challenges and ensure reliable results, a specialist sensor is required.
The InLab® Max Pro-ISM by METTLER TOLEDO is designed specifically for such samples. Its clog-resistant junction maintains uniform electrolyte flow, and its chemically resistant HA glass membrane delivers accurate and stable pH measurements across extreme pH values. With an integrated temperature probe and ISM chip for data storage, this sensor further simplifies the measurement process and enhances data integrity. All these features and a few others ensure accurate and reliable pH measurements of pharmaceutical suspensions.
Our application presents a pH measurement study on three suspensions: Triamcinolone Acetonide (TCA) Nasal Spray, Ibuprofen Oral Suspension, and Oxcarbazepine Oral Suspension. The study follows the USP's individual monographs and general chapter <791> on pH determination, using the METTLER TOLEDO InLab® Max Pro-ISM sensor. This sensor is also suitable for suspension samples according to other pharmacopeias, such as the European, Indian, and Chinese Pharmacopeias. Moreover, it highlights the importance of good electrochemistry practices for obtaining accurate and reliable results. Download it now to optimize your pH measurement process and ensure product quality.
Frequently Asked Questions
Why is measuring the pH of pharmaceutical suspensions important?
Measuring the pH of pharmaceutical suspensions is important because it can impact the safety and efficacy of the product. The pH value can affect the bioavailability, biological functions, microbial activity, and chemical behavior of the drug. Therefore, accurate pH control is necessary to ensure consistent quality and effectiveness of the medication.
What are the challenges of measuring the pH of pharmaceutical suspensions?
Measuring the pH of pharmaceutical suspensions can be challenging due to factors like particle interference, sensor clogging, and the risk of inaccurate readings. These issues can impact product quality and consistency if not addressed properly.
What is the significance of the USP monographs in pH measurement of pharmaceutical suspensions?
USP monographs provide specific guidelines for testing the quality and characteristics of pharmaceutical products, including pH measurements. They ensure that the products meet the required standards for safety, efficacy, and quality.
