Automatic Karl Fischer Titrator

EVA Volumetric KF Titrator - Speed Meets Reliability

Experience EVA Karl Fischer Titrators, where advanced engineering meets sophisticated software, designed to enhance precision and efficiency. Equipped with the Fast Forecasting Amperometric (FFA™) Algorithm and dSens M143 sensor, these titrators offer swift, accurate water content determination. The Swiss-engineered modular design caters to diverse lab needs, boosting throughput and accuracy.

Precise efficiency: Enhances speed and accuracy with FFA™ technology and rapid-response sensors.
Versatility: Adapts to any lab due to our modular engineering.
Seamless workflows: Streamlines with OneClick™ interface and LabX™ integration.
Optimal safety: Improves safety with advanced solvent management and spill prevention.
Regulatory compliance: Supports 21 CFR Part 11 and EU Annex 11 compliance.
Sustainable practices: Promotes paperless, efficient labs, reducing waste.

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This video explores the Fast Forecasting Amperometric (FFA™) Algorithm in EVA Karl Fischer Titrators. Learn how this advanced feature dynamically adjusts reagent concentrations for faster, more accurate titrations, significantly enhancing laboratory efficiency and precision in water content determination.

High Efficiency

Fast Forecasting Amperometric (FFA™) Algorithm: Optimizes reagent concentration with advanced control technology, speeding up reaction rates for rapid, precise water content determination.
Rapid-response digital sensor: Equipped with the interference-free dSens M143 sensor, delivering immediate and accurate data capture for reliable results.
Precision titrant addition: Utilizes a high-resolution dDrive unit with 120,000 steps, providing precise, dispensing that automatically adjusts to sample demands.

Swiss Engineering

Swiss craftsmanship: Known for their reliability and quality, these titrators are designed to meet the rigorous demands of modern labs.
Modular flexibility: Easily adapts and scales to changing lab needs with a wide range of configurations.
Versatile applications: Supports diverse industry requirements with extensive accessory options, ensuring compatibility across various sample types.

Seamless Workflow

Intuitive OneClick™ interface: Simplifies lab operations, enhancing usability for all skill levels.
Automated workflow: Instantly transfers sample weight data and titrant information, reducing transcription errors. Convenient features like automatic sample detection and method start enhance efficiency overall.
Seamless LabX™ integration: Connects with LIMS, ELN, MES, and CDS to reduce IT overhead and improve efficiency.

Regulatory Compliance and Traceability

EVA Karl Fischer Titrators integrate effortlessly with LabX™, enhancing data management and supporting Regulatory Compliance with standards like 21 CFR Part 11 and EU Annex 11. Key features include centralized user management, electronic signatures, and comprehensive audit trails. Adherence to ALCOA++ principles boosts data integrity while streamlining validation and maintenance.

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Optimal Safety

Advanced solvent management: Automates chemical dispensing to reduce exposure and leaks, ensuring a safer, cleaner lab environment.
Remote operation capabilities: Features a detachable touchscreen with a 2.5-meter cable and OneClick™ interface for safe, remote operation, reducing risks with hazardous substances.
Safety-driven design: Incorporates an enclosed system to prevent spills and minimize chemical handling, protecting users and maintaining consistent titration accuracy.

Sustainable Practices

EVA Karl Fischer Titrators, paired with LabX™, enhance sustainability by supporting paperless operations and reducing resource waste. These systems streamline workflows, optimize reproducibility, and minimize errors, promoting eco-friendly lab practices. Additionally, they now support ethanol-based reagents, offering a safer, sustainable alternative to methanol without compromising on speed or accuracy, making them ideal for modern, environmentally conscious laboratories.

EVA Karl Fischer Titrator V1

Precision simplified: The EVA V1 Titrator excels in determining water content and soluble samples with speed and accuracy. Perfect for routine testing, it combines simplicity with efficiency.

Titrator Karl Fischer EVA V1

Simplify Your Lab's Routine with Precision

Top performance: Measurement for simple liquids and solubles, ensuring fast and accurate water content determinations.
Ease of use: Designed with user-friendliness in mind, simplifying routine tests and making complex setups more manageable.
Optimal choice: ideal for labs aiming to boost productivity and operational excellence.
Streamlined operations: Enhance your lab’s throughput with an instrument crafted for high-volume testing with minimal complexity.

EVA Karl Fischer Titrator V3

Advanced versatility: The EVA V3 titrator simplifies water content determination in various samples. It allows for homogenizer attachment and external sample extraction for challenging samples.

Titrator Karl Fischer EVA V3

Master Complex Samples with Precise Efficiency

Broad sample compatibility: From semi-solids to challenging matrices, this titrator manages them all with speed and precision.
Homogenizer attachment: Prepares and integrates tough samples into a uniform solution for consistent, reliable analysis.
External sample extraction: Optimized for non-dissolving samples, this feature utilizes an extraction solvent to effectively extract water, safeguarding the main unit while managing reactive or corrosive samples.

Elevate your analysis with our specialized accessories, including thermostable vessels, homogenizer adapters, and drying ovens. These tools simplify the handling of challenging samples, ensuring precise results. Customize your Karl Fischer process with options like varied burette sizes and extended terminal cables for greater convenience and flexibility.

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Global Reach Meets Reliable Care

Installation and qualification: Provides professional setup, checks, and compliance training with IPac and EQPac for regulated industries.
Calibration and documentation: Ensures ongoing precision and compliance with regular calibration and dedicated software for traceability.
Extended care and support: Offers 24-month coverage and biannual maintenance backed by a global support network for minimal downtime.

Ensure Business Continuity with Global Support

Determining Water Content in Antibiotics Using a Thermovessel with EVA Karl Fischer Titrators

Use a thermovessel with the EVA Karl Fischer Titrator to measure water content in antibiotics accurately. The controlled temperature increase facilitates the effective release of water from solid pharmaceuticals, ensuring accurate and reliable analysis critical for quality assurance.

Analyzing Water Content in Gummy Bears Using EVA Karl Fischer Titrators

To accurately analyze water content in gummy bears, utilize the EVA V3 Titrator equipped with a homogenizer for fast and easy sample dispersion. This setup is ideal for efficiently determining water content in high-moisture food samples like gummy bears, ensuring precise and reliable analysis crucial for optimizing texture and shelf life.

Analyzing Water Content in Acetone Using EVA Karl Fischer Titrators

Acetone, a widely used organic solvent in many different market segments, reacts with methanol present in the KF reagents. As a result, additional water is produced, leading to higher water contents. Reliable and fast water content determination in acetone is achieved with the EVA Karl Fischer Titrators by using specific methanol-free reagents to suppress the side reaction. Read more

Performing General System Suitability Test (GSST) with Direct Injection Using EVA Karl Fischer Titrators

Prepare your sample according to the GSST protocol and utilize the direct injection feature of the EVA Karl Fischer Titrators for efficient analysis. This method enhances the precision and speed of water content determination across various samples, maintaining adherence to rigorous analytical standards. Read more

Determining Concentration with Sodium Tartrate Using EVA Karl Fischer Titrators

To obtain accurate results, it's crucial to determine the current concentration of the KF titrant precisely before beginning the sample titration. Sodium tartrate serves as an excellent reference material for this purpose. Be sure to weigh and dissolve it in the KF solvent with utmost precision. This crucial step will allow you to achieve a precise titrant concentration with your EVA Karl Fischer Titrator, ensuring the reliability of subsequent sample analyses. Read more

Determining Water Content in Tea Leaves Using External Extraction with EVA Karl Fischer Titrators

Insoluble solids release their water slowly into the KF solvent, leading to prolonged analysis times. External extraction shifts the time-consuming water extraction step to an external vessel. This ensures the EVA Karl Fischer Titrator isn't blocked for minutes or hours while the solvent extracts the water. Once the water content is extracted, it's transferred to the titrator for precise and thorough determination, meeting the specific needs of solid samples like tea leaves.

Analyzing Water Content in Honey with EVA Karl Fischer Titrators Using Formamide

Understanding the water content in food is essential for determining factors like product shelf life during storage and transport, as well as its edible quality. Accurately assessing water content is thus important in production processes and quality control. Since honey is difficult to dissolve in the KF solvent, formamide is used as an auxiliary solvent to ensure complete dissolution. This allows the water to be fully released and analyzed with the EVA Karl Fischer Titrator, leading to precise quantification and improved accuracy through proper sample preparation. Read more

Measuring Water Content in Edible Oils with EVA Karl Fischer Titrators

Increase the solubility of your edible oil samples in the Karl Fischer solvent using a mixture of chloroform and decanol. Analyze them by direct addition into the EVA Karl Fischer Titrator for precise and reliable quantification of water content, essential for assessing the quality and shelf-life of edible oils.

Advancing Lab Safety and Sustainability with Ethanol-Based Reagents in EVA Karl Fischer Titrators

EVA Karl Fischer Titrators support ethanol-based reagents, providing an eco-friendlier alternative to the conventional methanol. Traditionally, ethanol’s lower reactivity led to longer titrations and reduced accuracy. Thanks to advancements in measuring algorithms and modern reagent formulations, these issues have been resolved. Labs can perform accurate titrations with these safer and greener ethanol-based reagents enhancing sustainability without sacrificing speed and precision.

Learn How to Use a Karl Fischer Titrator

This video is designed to guide you through the entire process of setting up and maintaining your new EVA titrator. From the initial installation to routine self-maintenance, we'll walk you through each step so you can get the most out of your investment.

Want to Learn More? Check Out Our Guides:

Datasheet: EVA Volumetric Karl Fischer Titrator

Efficient Water Determination

Tips for volumetric Karl Fischer titration

Volumetric Karl Fischer Titration—Tips from Sample to Result

Useful Tips and Hints to Avoid Common Mistakes and Improve Results

FFA Amperometric Control Algorithm White paper

Understanding the FFA Amperometric Control Algorithm

Discover How the Control Algorithm Accelerates Accurate Water Content Determination with the EVA Volumetric KF Titrator

Weighing in Volumetric and Coulometric KF Titration

Weighing Excellence in Karl Fischer Titration

A Guide to Weighing Techniques in Volumetric and Coulometric KF Titration

FAQs

What is an EVA Volumetric KF titrator?

The EVA Volumetric KF Titrator is a device that uses Karl Fischer titration with a volumetric technique to determine water content in a wide range of samples, from 100 ppm to 100%. It's an effective tool for accurate water content analysis in various industries, including pharmaceuticals, food, chemicals, and more.

What kind of Karl Fischer titrations are EVA V1 and V3 based on?

The EVA V1 and V3 titrators are based on Volumetric Karl Fischer titration and use Amperometric indication.

What is the FFA™ KF control algorithm?

The FFA™ stands for Fast Forecasting Amperometric control algorithm, is used in the EVA V1 and V3 volumetric KF titrators from METTLER TOLEDO.

The FFA™ control relies on the measured signal of the dSens M143 digital polarized double platinum pin electrode, which detects the presence of water and calculates the amount of titrant to add to the system to compensate for it at a 10 Hz rate. The FFA™ also categorizes the chemical system in the KF cell based on the measured data, enabling it to automatically adjust control parameters to efficiently add the exact amount of titrant necessary to titrate all the water contained in a sample. Read more.

What are the advantages of the amperometric vs voltametric indication?

While both amperometry (UPol) and voltametry (IPol) can be utilized to measure a KF titration. Amperometric indication in Karl Fischer titration has the advantage of providing a linear relationship between iodine concentration and measured current, allowing for online forecasting of the necessary titrant volume and faster analysis times. In contrast, voltametric indication relies on a potential reading and can experience significant oscillations in slow iodine-water reaction situations, making it less sensitive around the endpoint of the titration.

What is the dead volume of the EVA burettes, and why is it beneficial to have a low dead volume?

A low dead volume is beneficial for burettes because it reduces the residual liquid in the burette after dispensing. The EVA titrator boasts an automatic burette emptying feature that replaces liquid with air. Dead volume, or the residual volume of liquid that cannot be displaced, poses a safety hazard during burette maintenance and cleaning. The EVA burettes have a very low dead volume of only 54 μL.

Can the EVA KF titrator analyze samples that are not soluble in Karl Fischer solvent?

Yes, the EVA KF Titrators can analyze samples that are not soluble in Karl Fischer solvent. The EVA V1 titrator has several applicative approaches to bring the water of an insoluble sample into the KF solution, including elevated temperature (by the use of a thermostatable vessel), internal extraction (by the use of auxiliary solvents), and gas-phase extraction (DO308 oven). However, for challenging samples, the EVA V3 titrator is recommended as it offers additional features such as homogenizers that crush the sample and bring the water into solution, blank methods to adjust the result for water entry during homogenizing, and external extraction, allowing users to extract water from the sample using a solvent and measure aliquots from the resulting solution.

Does the EVA titrator support the internal extraction of solid samples using a homogenizer and if so, which homogenizer models are compatible?

Yes, the EVA V3 titrator supports the internal extraction of solid samples via homogenizer. The following homogenizer models are supported:

IKA T25 Easy Clean digital; Tooling: S25N-18G (must be purchased separately)
Kinematica POLYTRON PT1300 D; Tooling: PT-DA 12/2 EC-E123 (must be purchased separately)

These homogenizers are automatically recognized when connected to the EVA titrator via USB A socket. The necessary USB cable is delivered along with the homogenizers. An adapter is also required to connect the homogenizer to the KF cell (material number 30869296 for Kinematica Polytron PT1300D and material number No 30869297 for IKA T25 Easy Clean digital).

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