Advancing Oligonucleotide Process Development Through PAT and Modeling
Bioprocess Optimization with Modeling and PAT
Program Overview
- Introduction to oligonucleotides
- PAT in oligonucleotide manufacturing
- Impact of excess water
- Reaction Kinetics with FTIR data
- TFF Modeling and Model Development
Jale Müslehiddinoğlu, Ph.D. of ST PHARM discusses the application of PAT in oligonucleotide manufacturing, focusing on the conjugation reaction and the use of ReactIR for real-time monitoring. She then presents a case study on tangential flow filtration (TFF) modeling, explaining the principles, parameter evaluation, and the use of Dynochem for predictions.
About the Presenter
Jale Müslehiddinoğlu, Ph.D.
VP of Strategic Innovation - ST PHARM
With 23 years in the pharmaceutical industry, began her career at BMS and later J&J, working across the full CMC lifecycle. She currently serves as Vice President of Strategic Innovation at ST Pharm, focusing on advancing technologies and partnerships in oligonucleotide.
