This page provides the method to accurately determine water content with volumetric KF titration using EVA titrator as per USP 921 method Ia.
By downloading this application package, you will receive a PDF of the application note as well as the required data for the LabX™ titration software method.
What is the significance of USP 921 method Ia?
To achieve consistent results worldwide, it is crucial to comply with international regulations. USP 921 method Ia specifies the method for titrator hardware and standards for endpoint detection. It outlines the criteria for determining when and how to conclude a volumetric Karl Fischer titration for measuring the water content in various samples.
How is the endpoint of the volumetric titration detected as per USP 921?
As per USP 921 method Ia, the method specifies the termination of volumetric KF titration to determine the water content in different samples. A slight excess of the reagent enhances the current flow, which is monitored by the electrodes for a minimum of 30 seconds. To ensure full compliance with this method, a relative drift stop criterion is applied along with a delay time of 30 seconds.
