ReactIR™ and ReactRaman™ are in-situ spectrometers that enable scientists to monitor reaction progression by measuring reaction trends and profiles in real-time, providing highly specific information about kinetics, mechanism, pathways, polymorph transitions, and the influence of reaction variables on process performance. ReactIR and ReactRaman provide critical information to scientists as they research, develop and optimize chemical compounds, synthetic routes, and chemical and crystallization processes.
Understand reaction kinetics, polymorph transitions, and mechanisms to optimize process variables. Read more
Raman spectroscopy yields information about intra- and intermolecular vibrations. The former provides a spectrum characteristic of the specific vibrations of atoms in a molecule and is valuable for identifying a substance, form and molecular backbone configuration to name a few. The latter yields information about lower frequency modes, which reflects crystal lattice structure and polymorph form.
Infrared spectroscopy's greatest value lies in its ability to probe the “fingerprint region” of the spectrum where intramolecular vibrations are well-defined and highly characteristic of the bonding of atoms.
A practical example of differentiation for these two technologies is in the investigation of a crystallization process, in which Raman analyzes solid crystal form(s) and IR measures the solution-phase characteristics such as supersaturation.
The instrumentation and interface to the sample for these two techniques are similar in approach, but different in the details.
Raman spectrometers utilize a laser as the source (typically visible or near-IR), whereas IR spectrometers typically employ a black body radiator (such as a glow bar) to provide energy in the mid-IR region.
Read more on the differences between Raman and FTIR instruments.
Although FTIR and Raman spectrometers are often interchangeable and give complementary information, there are practical differences that influence which one is optimal. Most molecular symmetry will allow for both FTIR and Raman activity. In a molecule that contains a center of inversion, IR bands and Raman bands are mutually exclusive (i.e., the bond will either be Raman active or IR active, but it will not be both).
One general rule is that functional groups that have large changes in dipoles are strong in the IR, whereas functional groups that have weak dipole changes or have a high degree of symmetry and no net dipole change, will be better seen in Raman spectra.
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METTLER TOLEDO is committed to not only maintaining carbon neutrality for our operations but also to establishing science-based targets to drive absolute reduction of greenhouse gas emissions across our operations and supply chain. Our products are designed in an environmentally responsible manner that minimizes adverse impacts on the environment.