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Home Expertise Library The Changing Role of PAT in Scale-up

The Changing Role of PAT in Scale-up

Bridging the Gaps From Process Development to Commercialization

The role of Process Analytical Technology (PAT) differs drastically when it is used for development, scale-up or production purposes. With such varying roles, changes in the number of techniques and frequency of use are often observed.

In the presentation, "The Changing Role of PAT From Process Development to Commercialization and Bridging the Gaps Between Them", Jan Dijkmans of Janssen, describes the differences and presents examples for each of these roles.

Topics include:

  • The use of PAT from lab to plant
  • PAT to verify or deny correct scale-up
  • Process fingerprinting
  • Recent advances on how to bring PAT data from the lab into the plant for live verification and analysis during scale-up

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The role of PAT differs drastically when it is used for development, scale-up or production purposes. With such changing roles, changes in the number of techniques and frequency of use are also observed. In this talk, these differences are described, and examples are shown for each of the roles. The talk then focusses on lab-to-plant scale-up. How can PAT be used to verify or deny a correct scale-up and, in the latter case, help in finding out why the scale-up was not successful. The fingerprint concept is explained, as well as recent advances on how to bring PAT data from the lab into the plant to allow for a Live verification and data analysis during batch scale-up.

About the Presenter

jan dijkmans

Jan Dijkmans, Ph.D.

Janssen

Jan obtained his Master's degree in Bioscience Engineering from the University of Leuven, Belgium. He then joined the group of Professor Bert Sels where he developed heterogeneous catalysts for Biomass conversion to chemicals, focusing on incorporation of Sn into zeolite structures. He received his Ph.D. in Bioscience Engineering in 2015. After a one-year post-doc project collaborating with Total Petrochemicals, Jan joined Janssen Pharmaceuticals (Johnson & Johnson). In his role as Process Engineer, he develops robust processes, using a combination of data-rich experimentation, modelling, data analysis and technology. He is the department's PAT subject matter expert. In this role, he supports colleagues when performing or analyzing PAT experiments and improves the implementation of the technologies during development and scale-up of processes.