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Check out our detailed guide on volumetric Karl Fischer titration, including guidelines from the US and European Pharmacopeias for consistent and reliable results. |
Volumetric Karl Fischer titration (KF titration) is a selective method used to determine water content in pharmaceuticals. It involves the reaction between iodine, sulfur dioxide, and water molecules in the presence of a suitable solvent and base. The electric current monitored during the reaction is used to analyze the water content in the KF titration.
Explore our comprehensive guide, which provides all the necessary information about volumetric Karl Fischer titration and the guidelines established by the US Pharmacopeia and European Pharmacopoeia to ensure consistent and reliable results.
USP and Ph. Eur. guidelines for volumetric KF titration
The US Pharmacopeia and European Pharmacopoeia have established guidelines and regulations to be followed when conducting volumetric KF titration for water content determination in pharmaceutical samples. These guidelines ensure that the results obtained are standardized, reliable, consistent, comparable, and acceptable across pharmaceutical industries.
Steps involved in volumetric KF-titration
The volumetric method involves adding an appropriate amount of Karl Fischer reagent to the sample until the water completely reacts and the endpoint is reached. Automation allows for unattended operation and precise measurements of water content.
If you want to learn about water content determination, volumetric Karl Fischer titration is a reliable and accurate method used in the pharmaceutical industry. The US Pharmacopeia and European Pharmacopoeia have established guidelines and regulations for using this method to ensure consistent results. Learn more about this method and its guidelines by downloading our guide now.
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