The XPR Automatic Balance combines high-precision weighing with automation to dispense powders and liquids with extremely high accuracy. It supports companies across various industries on their journey to automation, enabling sustainable innovation and lasting gains in performance.
 |
Dispense in Milligrams
Get repeatable dispensing results with garanteed accuracy down to less than 1 mg. Use for both manual and automatic weighing to optimize your weighing processes.
 |
Prepare Solutions and Dilutions
Eliminate user error, increase accuracy, and save time.
 |
Fill Capsules, Vials, and Bottles
Improve ergonomics and limit exposure to hazardous substances.
Jump to one of the following sections to explore and learn more:
- XPR Automatic Balance – Three Balances in One!
• Solution Preparation and Dilutions—Solved
•Powder Handling Made Easy
• Say Goodbye to Manual Capsule Filling
• Screen Dozens of Substances with a Click - Options for XPR Automatic Balance Configurations
- Discover the Accessories
- Success Stories
- Frequently Asked Questions
Solution Preparation and Dilutions—Solved
The preparation of solutions and dilutions has never been easier or more precise.
First, dispense powders automatically or manually. Then, our auto-dilutor dispenses the exact amount of solvent to achieve a target concentration.
- Achieve a dilution factor of 10’000 in a single step (at ca. 100 ml total volume)
- Improve HPLC, ICP (ICP MS, ICP OES), or NMR analysis results drastically
- Work with a volumetric flask or pre-defined volumetric concentration follow standard SOP
Powder Handling Made Easy
Simply store your powders in our dosing heads and let the automatic balance do the rest! Our dosing heads connect directly to the automatic balance for precise dispensing of almost any powder, even if they are electrostatically charged, acidic, hygroscopic, or sticky.
The automatic balance can:
- Dose quantities below 1 mg at a readability of 2 µg
- Be placed in a safety cabinet and glove box
- Prepare 30 samples in one run using a sample changer
- Reduce waste from over- or underfilling
Say Goodbye to Manual Capsule Filling
The XPR Automatic Balance paired with a sample changer automates dosing various APIs, and it is often used in pre-clinical studies. The sample changer drives further process innovation:
- Narrow tolerances (e.g. 1%) at 4 mg USP minimum weight possible
- Dispense 3x faster than filling capsules manually
- Use in a safety cabinet or glove box for user safety
- Fill up to 30 capsules from sizes 000-4 in a single run
- Fill different amounts of API in each capsule
Screen Dozens of Substances with a Click
For increased speed and throughput, the CHRONECT system combines the advanced weighing and dispensing technology of the XPR Automatic Balance with a 6-axis robotic arm.
- Fully automatic weighing of up to 288 samples
- Dispensing of 6 liquids and 32 powders
- Additional modules including capping, vortexing, dilution, and heating
For high-throughput preparation of compounds that involve dispensing small quantities of hundreds of substances (less than 10 mg) into small vials, this is a widely adopted solution.
 |
Powder and Liquid Dispensing
The Q3 dosing module is an upgrade for an XPR Analytical Balance enabling both powder and liquid dispensing. Depending on the target min-weight or maximum capacity, the appropriate balance can be chosen.
 |
Liquid Dispensing Only
The QLX3 dosing module can dose liquids only. It is suited for dilutions or processes in which powders are dispensed manually and an exact solution is obtained with automatic liquid dispensing.
 |
Sample Changer
The sample changer is an upgrade for the XPR Automatic Balance that allows for the automatic dispensing of up to 30 samples of powders and liquids in a single run.
Accessories
 |
Vial Adapters
A range of adapters allows dispensing into a variety of containers including vials, bottles, capsules, and tubes.
The adapters come in different diameters, allowing you to work with your vial of choice.
 |
Dosing Heads
Powder and liquid dispensing heads are available for substances with a wide range of characteristics.
A powder dosing head starter kit is available to help you determine which heads best suit your needs.
 |
Other Accessories
Many accessories are available for the XPR Automatic Balance such as printers, USB Hubs, RFID readers, ErgoClips, antistatic kits, and more.
Success Stories
 |
Improving the Outcome of Pre-clinical Studies
A customer from the pharmaceutical industry spent hours filling capsules manually every day for pre-clinical studies. Each capsule was filled by hand with a different amount of API. The weighing process was time-consuming, error-prone, and difficult.
After the preparation of the dosing head and the definition of the quantities per capsule in LabX, 30 capsules are filled automatically. The results are impressive:
- Operator time was reduced from ca. 75%
- Sample waste was reduced to almost zero, saving ten-thousands of dollars in API costs
- Increased accuracy of the pre-clinical study outcomes
- Full audit compliance achieved with LabX™
- Increased operator safety with less API exposure
 |
Increasing Precision of HPLC Measurements
A customer in the chemical industry was looking for process improvements in the production of reference materials for residue analysis with HPLC and GC. The formulation of dozens of dry powders for subsequent solution preparation and dilutions was time-consuming and frequent errors led to significant rework.
Today, the customer stores their reference materials in dosing heads. Using LabX™, the operator follows a simple workflow through the dispensing process of both powders and liquids.
- Operator time and sample amounts were reduced by 75%
- HPLC calibration curves reached the highest regression values
- Manual dispensing errors were eliminated
Related Content
FAQ
Automatic Weighing - FAQ
- For which applications can I use automatic weighing?
- What is an automatic weighing balance?
- How can I improve the efficiency of sample preparation?
- What is gravimetric sample preparation?
- What is the lowest amount I can weigh automatically?
- How much time and sample can I save using automatic weighing?
- How can I safely weigh potentially hazardous samples?
- What are the tricks to improve capsule filling?
For which applications can I use automatic weighing?
Multiple applications in various industries can benefit from automatic weighing, such as bottling for sales, sample preparation, capsule filling, or screening. Automatic scales are widely used in industries such as fine chemicals, pharmaceuticals, CROs, CDMOs, or testing labs.
What is an automatic weighing balance?
The automatic balance can automatically dispense powders and liquids with high accuracy, in addition to performing solution preparation and serial dilutions. It improves workflows of sample preparation in the lab for qualitative and quantitative analysis of various analytical techniques including HPLC, GC, ICP, and NMR.
How can I improve the efficiency of sample preparation?
An automatic balance greatly reduces time spent on sample preparation. To further increase efficiency, an automatic balance can be upgraded with a sample changer, which can prepare samples while the operator focuses on other tasks in the lab.
What is gravimetric sample preparation?
Gravimetric sample preparation is weighing a sample, either manually or using automation, and then delivering the required amount of solvent to achieve a desired concentration. The solvent amount is calculated based on the actual amount of sample weighed and measured by its weight rather than volumetrically.
What is the lowest amount I can weigh automatically?
METTLER TOLEDO automatic balances (XPR226DRQ and XPR106DUHQ) show reliable performance for target weights above 0.30 mg. At this weight, 93% of measurements did not deviate more than 20% from the target weight.
How much time and sample can I save using automatic weighing?
The exact savings can be counted using a return-on-investment calculator. It can vary depending on the task time when working manually and sample costs. Generally, approximately 75% can be saved on sample and time when preparing the samples automatically.
How can I safely weigh potentially hazardous samples?
An automatic scale is the perfect solution for weighing hazardous samples. The system can work with limited technician interaction and can be easily placed in safety enclosure or glove box.
What are the tricks to improve capsule filling?
An automatic balance with a sample changer is a useful solution for filling small batches (up to a few hundred) of capsules. Every capsule can be filled with a different amount of samples if necessary. This automated solution includes a specially designed powder dosing head in order to avoid spillage, error, waste, and save time.