The safety and quality of pharmaceuticals and biopharmaceuticals rely on the quality of the water supply.
While water-testing labs ensure water safety through a multitude of single or automated analytical measurements such as pH, conductivity, hardness, alkalinity, and turbidity, advanced in-line measurement systems for water provide a high-quality and reliable solution to industries where compliance, calibration, validation, and verification of their water systems are required.
In-line monitoring and control of the entire water treatment, storage, and distribution systems provide pharmaceutical and biopharmaceutical facilities with a pathway to the process analytical technology (PAT) initiative while ensuring that pharmacopeia requirements are met.
Selecting the appropriate water quality control procedures, correct purification technologies,and instrumentation to monitor the system is critical to success.
METTLER TOLEDO laboratory instruments are ideal for punctual water quality checks in the laboratory and at-line applications, while Thornton instrumentation monitors all stages of water purification in-line
Water purification steps and online monitoring opportunities:
1. Filtration: conductivity and pH
2. Softening: conductivity
3. Carbon Adsorption: ORP
4. Reverse Osmosis: conductivity, pH
5. Optional – deionization or electrodeionization: conductivity, sodium, silica
6. Distillation: conductivity, TOC
7. Ultraviolet irradiation: ozone, TOC
8. Ozone disinfection: ozone
The purification of water used in the pharmaceutical industry requires a series of steps to remove the impurities, minimize contamination, and avoid biofilm growth.
Measuring conductivity, total organic carbon (TOC), ozone, and microbes online and in real time in pharmaceutical waters is important for optimizing water monitoring.
Traditional sampling methods are common but do not have the advantages of continuous measurements that lead to optimized water quality and compliance with industry standards.
Offline water analyses are recommended to be performed punctually to verify the accuracy of the online monitoring system, with applications for benchtop instruments such as density, refractive index, pH, conductivity, ions and dissolved oxygen (DO), titration, and UV-Vis measurements.
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For an analytical measurement to be accurate and appropriate for your process, you need more than just the right equipment, you need the right setup and configuration.
METTLER TOLEDO offers post-installation configuration services for your measurement point to ensure that you get the measurement data you need.
METTLER TOLEDO Service is your one-stop shop for all your inspection device service needs.
Our global network of factory-trained technicians is dedicated to providing expert care for your devices.
From installation and initial calibration to preventive maintenance and timely upgrades, we ensure your operations run smoothly and efficiently.
