An online water bioburden analyzer is a rapid microbial method for measuring microbial contamination in pharmaceutical grade waters. It offers a real-time microbial monitoring solution, providing continuous results every two seconds for better control of your water system. The 7000RMS rapid bioburden analyzer uses advanced, laser-induced fluorescence and Mie scattering technology to provide immediate detection and quantification of microorganisms.
The real-time microbial detection analyzer 7000RMS combines two well-established measurement technologies, laser-induced fluorescence and Mie scattering. The microbial analyzer counts individual microorganisms present in pharmaceutical water. Without collecting a sample or waiting days for plate count results, the 7000RMS delivers instant real-time monitoring of bioburden contamination.
Providing continuous results every two seconds, this real-time microbial analyzer requires no sample preparation or incubation period, eliminating delays in product release.
The 7000RMS microbial detection analyzer eliminates the variability and time-consuming nature of traditional plate counting with rapid microbial monitoring to ensure water quality.
Combining two well-established measurement technologies, the bioburden analyzer uses laser-induced fluorescence and Mie scattering to count microorganisms in pharmaceutical grade water systems.
With the ability to monitor water system trends prior to an out-of-specification event, the real-time microbial analyzer helps to identify the root cause of contamination events.
Rapid microbial monitoring with the 7000RMS online water bioburden analyzer gives you full visibility of changes in contamination levels to reduce risk and ensure water quality for release.
The 7000RMS bioburden analyzer provides microbial detection of organisms down to 0.3 micron, and the technology does not rely on the formation of colonies like traditional plate counting methods.
Use continuous trending data with the rapid microbial method to establish a baseline and monitor any shifts before and after sanitization to determine a cycle's frequency and effectiveness.
METTLER TOLEDO Thornton’s 7000RMS™ is an on-line analyzer for real-time measurement of microbial contamination (bioburden) in pharmaceutical water. Laser-based technology enables immediate detection and quantification of microorganisms directly from the water sample, overcoming limitations of time-consuming growth-based methods. Read more
The METTLER TOLEDO Thornton 7000RMS (Real-time Microbial Detection System) is suitable for monitoring microbial contamination in high purity water systems such as Purified Water (PW) and Water For Injection (WFI) systems by the synchronized optical detection of particle scattering and fluorescence from bacteria metabolites. Read more
The 7000RMS™ combines two well-established measurement techniques, laser-induced fluorescence and Mie scattering, to count individual microorganisms present in pharmaceutical grade waters. The 7000RMS delivers continuous, 24/7 monitoring of bioburden contamination without collecting a sample or waiting days for plate count results. Read more
Expert system services provide peace of mind and ensure that your analyzer is performing optimally to deliver process control. Our skilled technicians provide thorough inspection, cleaning and operational testing to ensure there are no out-of-specification performance issues at each recommended maintenance and calibration interval. Read more
Culture-based lab measurements of microbes can create challenges. Microbial monitoring in Purified Water, Ultrapure Water and Water for Injection has almost exclusively depended on time-consuming and error-prone culture-based lab measurements. Read more
We support and service your measurement equipment through its entire life-cycle, from installation to preventive maintenance and calibration to equipment repair.
There are numerous ways to measure microbial contamination of water, and USP recommends specific ways for pharmaceutical waters.
Traditionally, plate count methods are widely used for releasing water; however, they are prone to error and can take 5-7 days to obtain results. Plate counting also requires the formation of a colony of bacteria on a plate, and hence, the measurement unit is called the 'colony forming unit' or CFU, which estimates the total number of bacteria present in the sample plate.
Another way of measuring microbial contamination in water is through laser-induced fluorescence with a microbial detection analyzer. These analyzers use laser-induced fluorescent technology to measure the total number of cells that are present in the sample volume of water. Systems that use this technology allow at-line, real-time monitoring of microbial contamination in pharmaceutical waters by identifying cells present in the sample water immediately and are reported as auto-fluorescent units (AFUs).
Auto fluorescent units, or AFUs, are individual microorganisms reported in cells/mL. The 7000RMS illuminates the sample with a laser, resulting in Mie scattering from any particle present in the sample and florescent scattering from metabolites (NADH and riboflavin) present in all bacteria.
With advanced algorithms and sample processing, the 7000RMS analyzes and reports the number of cells/bacteria in the water sample as AFU.
The Microbial Detection Analyzer 7000RMS is a real-time monitoring system designed to detect and quantify microbial contamination. When used in parallel with plate counting, this bioburden analyzer offers a rapid microbial method (RMM) solution for better microbial control of your water system, reducing the risk of releasing contaminated water and improving process control.
The bioburden analyzer uses laser-induced fluorescence and Mie scattering to monitor results continuously every two seconds. This can improve process transparency and help significantly reduce costs.
The 7000RMS online water bioburden analyzer has various applications. It measures microbial contamination in Pharmaceutical-Grade Waters, including Pure Water (PW), Ultrapure Water (UPW), and Water for Injection (WFI), in any industry where they are used.
The 7000RMS bioburden analyzer provides microbial detection of organisms down to 0.3 microns. The technology does not rely on the formation of colonies like traditional plate counting methods.
When used in conjunction with plate counting, this online water bioburden analyzer provides a rapid microbial method (RMM) solution. It is designed to enhance your process control by regularly giving you a comprehensive understanding of your entire water loop. This will improve process transparency, enabling you to act promptly in case of an excursion event.
Furthermore, the analysis time is continuous, and the analyzer provides results every two seconds, requiring no sample preparation or incubation period.
