Daiichi Sankyo have developed an automated sampling and quantitative HPLC analysis system by combining EasySampler with Shimadzu's HPLC and switching valve (FCV-20AH2).
Normally, the EasySampler collects reaction aliquots from solution, prepares diluted samples, and stores them in a vial carousel for subsequent off-line analyses. In this study, instead of using the EasySampler vial carousel, the tubing was connected to HPLC and investigated an automated on-line quantitative analysis in real time. After optimizing the conditions, we confirmed that the accuracy and reproducibility were sufficient for practical use.
Makoto Michida
Process Chemist, Daiichi Sankyo
Makoto Michida is a process chemist at Daiichi Sankyo for 25 years, with recent interest in lab automation and automating medium-scale synthesis experiments. His expertise and passion for automation have been recognized, and he is expected to contribute to future research in the field.