Accessing Cycloparaphenylenes and Azobenzenes via Flow Chemistry
Streamlining Organic Synthesis
Program Overview
- Do's and don'ts for flow chemistry for organic synthesis
- Presentation of different option of flow reactors
- Successful transition of batch to flow chemistry
After a general introduction into flow chemistry, we present two case studies, highlighting the advantages as well as the potential pitfalls of flow chemistry in organic synthesis. In the first study, we developed a flow chemistry based synthetic strategy to cycloparaphenylenes. Flow chemistry allowed access to someof the building blocks on a kilogram scale. In the second study, we prepared azobenzenes in flow. Here, we used in-line IR spectroscopy to optimize and monitor the process.
About the Presenters
Prof. Dr. Hermann A. Wegner
Professor of Organic Chemistry, Justus Liebig University
Hermann A. Wegner studied Chemistry at the Georg-August University, Göttingen, Germany, and Boston College, USA. He received his PhD at the Georg-August University, Göttingen Germany, under the supervision of Prof. Dr. Armin de Meijere with a research stay at Stanford University. After a Postdoc in the group of Prof. Dr. Sir Jack Baldwin at Oxford University, UK, he started his independent career at Basel University, Switzerland. In 2013, he moved to his current position as Professor of Organic Chemistry at the Justus Liebig University, Gießen, Germany. His research interests lie in physical organic chemistry and its application to molecular materials for energy management.
Dr. Jan H. Griwatz
Laboratory Head IDD - Synthetic Molecular Design/Medicinal Chemistry, Sanofi
Jan H. Griwatz studied chemistry at the Justus-Liebig-University Giessen in Germany. He completed a PhD in organic chemistry at the same university under the supervision of Prof. Wegner, and his work focused on the development of continuous flow synthesis and organic materials. He could gain additional expertise in this field during a research placement with Dr. Tagmatarchis' group at the National Hellenic Research Foundation in Athens, Greece. He recently joined Sanofi as a laboratory head in medicinal chemistry.
