This white paper introduces some of the most common particle size analysis approaches and how they can be deployed for the effective delivery of high-quality particle products. Specifically, scientists are now combining offline particle size analyzers with in-process particle characterization instruments to optimize and improve processes. Examples are given where this combined approach enables scientists to:
- Obtain detailed process understanding by directly measuring changes to particle size and count as process parameters vary
- Determine operating conditions required to deliver fit-for-purpose particles on a consistent basis
- Monitor and correct process deviations during continuous or batch production
- Avoid time delays and errors associated with sampling, preparation, and offline analysis
Common applications include crystallization, emulsification, suspensions, flocculation, dispersion, homogenization, wet milling, polymerization, microencapsulation, oil-water separation, disintegration, and dissolution.