Flow and Batch Chemistry Monitoring
Reaction Endpoint Determination, Distillation Monitoring, & Multi-Instrument Calibration
Program Overview
- Batch reaction endpoint determination using a rate of change confidence interval algorithm
- Continuous flow chemistry reaction status monitoring and scale-up
- Vacuum distillation monitoring via the headspace vapor condensate
- Multivariate calibration model developed with multiple instruments and probes that demonstrates transferability and agreement with offline NMR and Aspen modeling data
Charles Goss presents recent examples illustrating how GlaxoSmithKline (GSK) monitors flow and batch chemistry unit operations in both laboratory and pilot plant reactors. Join over 500 researchers who have already viewed this presentation.
About the Presenter
Dr. Charles Goss
Analytical Chemist, GlaxoSmithKline
Charles Goss is currently an Analytical Chemist at GlaxoSmithKline, where he provides support to cross-functional drug development teams responsible for supplying the Active Pharmaceutical Ingredient (API) or formulation used in pre-clinical and clinical studies. Dr. Goss serves as a technical resource in several areas, including process monitoring, separation sciences, electrochemistry, microscopy and new analytical technologies. Dr. Goss earned his BA in Chemistry from Cornell University and a Ph.D. in Physical Chemistry from the University of California at Berkeley. He was a Post-Doctoral Fellow with Prof. Royce Murray at UNC-Chapel Hill. Dr. Goss pioneered in situ AFM and other methods to image electrochemical deposition of ultrathin (5-10 nm) dielectric polymer films, create laterally heterogeneous polymer nanostructures, and characterize surface blistering and layer-by-layer dissolution of graphite during anodic oxidation. Dr. Goss was a Post-Doctoral Fellow in the Analytical Development Laboratories at Burroughs Wellcome Co. where he helped to construct a high-sensitivity laser-based optical rotation detector for HPLC. Dr. Goss optimized performance and used it to determine enantiomeric purity, identify impurities, and to measure specific rotations for difficult samples. Dr. Goss developed new analytical methods to support drug development.
