The manufacturing process for CGT involves several complex steps to ensure therapies are safe, effective, and high-quality.

Cell culture

Cell culture

Cell culture starts with preparing a nutrient-rich medium to grow and maintain healthy cells.

Monitoring pH and conductivity ensures optimal conditions. Cells are then expanded in a bioreactor until they reach the desired quantity.

Harvesting

Harvesting

Once cells have grown sufficiently, they are harvested by separating them from the growth medium through centrifugation and filtration to remove impurities and prepare them for further processing.

Purification and Formulation

Purification and Formulation

Harvested cells are purified to remove contaminants, ensuring the therapy's safety and efficacy.

Finally, purified cells are formulated into a final product for patient administration.

Quality Assessment in CGT

Quality Assessment in CGT

Quality assessment is critical at every stage of CGT manufacturing to ensure therapies are safe and effective.

Various analytical methods monitor and verify the quality of raw materials, intermediate products, and final therapies.

Analytical Sensors for Bioreactors

Analytical Sensors for Bioreactors

Accurate Process Control in Fermentation & Cell Culture

automated-reactor

Automated Lab Reactors and In-Situ Analysis

Instruments for Chemical Synthesis, Process Development, and R&D

dynochem biologics

Dynochem Biologics

Bioprocess Simulation Software

CytoDirect automated cell counting used in the biolab under the hood

Cell Analysis

Automated Cell Counter

Analytical balances - Laboratory balances

Analytical Balances

High-Performance Weighing Equipment for the Laboratory

METTLER TOLEDO Precision Balances

Precision Balances and Scales

Accurate and Precise Weighing Equipment for the Laboratory and Manufacturing

Plate Readers / Microplate Readers

Plate Readers / Microplate Readers

Efficiently Measure Samples with Our High-Quality Microplate Reader – PlateDirect A96

UV Vis Spectrophotometry by METTLER TOLEDO

UV/Vis Spectrophotometry

Instruments, Accessories, Services, and Software for UV Vis Spectrophotometry

lab pH instruments

Lab pH Instruments

pH and Conductivity Measuring Solutions for Laboratory and Field Applications

Industrial Scales and Weighing Scales

Industrial Weighing Scales and Systems

Accurate weighing scales and reliable weight scale for various scale base types

Biopharmaceutical Manufacturing Guide

Biopharmaceutical Manufacturing Guide

This guide covers the role of analytics and weighing in understanding these parameters in upstream a...

Cell and gene therapy QC with UV Vis

The Right Analytical Solutions for Cell and Gene Therapy

Determining the concentration and purity of DNA samples is a routine task in gene and cell therapy....

Demonstration of Inline Particle Analysis PAT for Bioprocess Harvesting

Webinar: Demonstration of Inline Particle Analysis PAT for Bioprocess Harvesting

In this webinar, we discuss how inline image analysis in real-time gives insights into process mecha...

pDADMAC Flocculation Case Study

pDADMAC Flocculation Reagent Studies

Tyle Gable of METTLER TOLEDO presents two case studies for pDADMAC pre-treatment process optimizatio...

Oligonucleotide Synthesis

Oligonucleotide Synthesis

Oligonucleotide synthesis is the chemical process by which nucleotides are specifically linked to fo...