The Mettler-Toledo Thornton 450TOC Portable TOC Analyzer measures the amount of organic carbon in high purity waters by oxidizing organic carbon to CO2 with appropriate UV radiation. The resulting change between two temperature-compensated conductivity measurements of the sample flow stream at points before and after oxidation is used to calculate the amount of total organic carbon present.
Scope
This document provides procedures to calibrate the Thornton 450TOC Portable TOC Analyzer (PN 58 036 041). This
document provides strategies for the frequency and content of “As Found” data and the calibration process with respect to lamp
changes and performing System Suitability Tests (SST) to meet specific pharmacopeia requirements.
Calibration Process
The complete calibration of the 450TOC Portable TOC Analyzer consists of calibration of the following:
- Flow rate sensor measurement
- Two temperature sensor measurements
- Two conductivity sensor measurements
- TOC measurement
Sequence of Operations for Calibration, SST and Lamp Changes
When performing a calibration, the sequence of operations depends on other process decisions. For example:
- If a lamp change is intended, does “As Found” data need to be collected?
- Is an SST scheduled during this time?
- If an SST is required, does “As Found SST” data need to be collected?
- Is a TOC calibration required, or is a full calibration for TOC, conductivity, and temperature required?